Results 101 to 110 of about 1,378,543 (295)

An n‐of‐1 gene‐directed drug repurposing trial for an ultrarare genetic condition

Epilepsia, EarlyView.
Abstract Objective Gain‐of‐function (GoF) variants in the KCNC1 potassium channel subunit gene (Kv3.1) cause motor/cognitive delays and hypotonia and have been associated with seizures. Fluoxetine has inhibitory effects on Kv3.1. However, open‐label nonrandomized administration is insufficient to guide clinical decision‐making in ultrarare conditions ...
Vedika Jha, Christina Tsetsos, Mark Bedford, Gregory Costain, Sunita Vohra, Juan Pablo Diaz Martinez, Elise Heon, Jacob Vorstman, Carolina Gorodetsky, Ajoy Vincent, Jesiqua Rapley, Lori Anderson, Evdokia Anagnostou, Danielle A. Baribeau   +13 more
wiley   +1 more source

WONOEP XVII appraisal: The role of the extracellular matrix in epilepsy

Epilepsia, EarlyView.
Abstract The extracellular matrix (ECM) is composed of proteoglycans and glycoproteins that regulate the external environment surrounding neurons, glia, and the vascular system. The ECM is vital for maintaining the structure and function of the brain and also acts as a reservoir for various signaling molecules and neurotransmitters, modulating synaptic
Eleonora Lugara, Erwin A. van Vliet, Alessia Romagnolo, Kevin Staley, Kyle P. Lillis, Chris Dulla, David C. Henshall, Katja Kobow   +7 more
wiley   +1 more source

Pablo Lafargue Pablo Lafargue Armagnac en la historiografía cubana

Revista Opinião Filosófica
Pablo Lafarge fue cubano de nacimiento y francés por adopción.  Cercano colaborador de Marx y Engels, contribuyó a difundir y divulgar la nueva teoría, la defendió de aquellos que pretendían vulgarizarlas.
Luisa María Cuevas Pino, Lidice Duany Destrade   +1 more
doaj   +1 more source

Further Findings on the Intergenerational Transmission of Alcohol Consumption

Health Economics, EarlyView.
ABSTRACT Using 43,817 parent–child pairs from 23 waves of the HILDA Survey, I study the intergenerational transmission of alcohol use within a rational model of trait transmission. Transmission is predominantly same‐sex: the mother–daughter elasticity is 0.10 and the father–son elasticity is 0.09; there is no father–daughter effect.
Sergey Alexeev
wiley   +1 more source

Gerchunoff, Pablo y Pablo Fajgelbaum. ¿Por qué Argentina no fue Australia? Historia de una obsesión por lo que no fuimos, ni somos, pero... ¿seremos?

H-Industri@, 2019
Reseña de: Gerchunoff, Pablo y Pablo Fajgelbaum. ¿Por qué Argentina no fue Australia? Historia de una obsesión por lo que no fuimos, ni somos, pero... ¿seremos? (2° edición ampliada).
Pablo J. Mira
doaj  

Patient‐ and caregiver‐reported barriers to radiotherapy for cancer in sub‐Saharan Africa—A survey of population‐based registries

International Journal of Cancer, EarlyView.
What's New? Low‐ and middle‐income countries have over 70% of the global cancer burden but 10% of the world's radiotherapy capacities. This population‐based multi‐country study explores the barriers to access experienced by cancer patients in sub‐Saharan Africa.
Eric Sven Kroeber, Tamara König, Ole Stöter, Biying Liu, Phoebe Mary Amulen, Margaret Borok, Gladys Chesumbai, Eric Chokunonga, Ima‐Obong Ekanem, Mahine Ivanga, Bakarou Kamaté, William Muller, Abidemi Omonisi, Jean‐Félix Peko, Mathewos Assefa, Furaha Serventi, Markus Wallwiener, Mazvita Muchengeti, Pablo Sandro Carvalho Santos, Donald Maxwell Parkin, Eva Johanna Kantelhardt, Nikolaus Christian Simon Mezger   +21 more
wiley   +1 more source

The We‐Relationship as a Key to Addressing Dementia‐Related Ambiguous Loss

Journal of Applied Philosophy, EarlyView.
ABSTRACT Pauline Boss describes the challenges faced by people caring for family members with dementia in terms of ambiguous loss – a condition in which the physical presence of the person with dementia coexists with their psychological absence. This article proposes the concept of we‐relationship as a key to addressing dementia‐related ambiguous loss.
Takuya Niikawa, Xue Li
wiley   +1 more source

1,000 Holes in the Wall [PDF]

Co-authored research paper written with José Vela Castillo on the subject of Pablo Román's wall of 1,000 images, Vienna, 2013. “Vienna” or “The Wall” is an ongoing project by architect/artist Pablo Román that, upon its completion ...
Keeney, Gavin
core  

Adolescents' trajectories of mental health in the MYRIAD trial

JCPP Advances, EarlyView.
Abstract Background This study explored adolescent's mental health trajectories over the course of a school‐based mindfulness‐based intervention trial (MYRIAD). It examined whether intervention condition (mindfulness vs. teaching‐as‐usual), individual‐level and contextual‐level factors were associated with different trajectories.
Carolina Guzman Holst, Simona Skripkauskaite, Jack L. Andrews, Jesus Montero‐Marin, Verena Hinze, Tim Dalgleish, Willem Kuyken, MYRIAD team, Lucy Foulkes   +8 more
wiley   +1 more source

Cost‐effectiveness and long‐term outcomes of periodontal regeneration versus dental implants: A retrospective study

Journal of Periodontology, EarlyView.
Abstract Background Direct comparative data on periodontal regeneration (PR) versus extraction and implant placement remain limited. Tooth‐specific periodontal conditions such as furcation involvement and overall tooth prognosis may dictate success or failure of such treatment.
Yousef T. Amrou, Abdusalam E. Alrmali, Hamzeh Almashni, Pablo Galindo‐Fernandez, Hom‐Lay Wang, Muhammad H. A. Saleh   +5 more
wiley   +1 more source