Results 1 to 10 of about 4,046 (110)

Cardiac fibrosis induced by high-fat diet in ApoE-deficient male mice is exacerbated by genetic deletion of PACAP-PAC1 signaling. [PDF]

J Neuroendocrinol
Abstract Cardiac fibrosis is characterized by an excessive accumulation of extracellular matrix proteins and occurs in a variety of cardiac diseases, such as the highly prevalent syndrome heart failure with preserved ejection fraction (HFpEF) and other cardiac disorders.
Schubart JM, Schaefer MKH, Bonaterra GA, Mey L, Schwarzbach H, Pankuweit S, Ausbuettel F, Eiden LE, Weyand S, Weihe E, Kinscherf R, Waechter C.   +11 more
europepmc   +2 more sources

Communicative Justice in Later Life: A Critical Discourse Study and Bioethics-of-Vulnerability Analysis of Older Adults' Primary Care in Spain. [PDF]

Nurs Inq
ABSTRACT Older adults' experiences of primary care are shaped not only by service capacity but by the language and routines through which access and care are organised. Using a qualitative Critical Discourse Studies (CDS) approach informed by the bioethics of vulnerability, we analysed interviews and focus groups with 12 community‐dwelling older adults
Martínez-Angulo P, Millán-Eslava MJ.
europepmc   +2 more sources

PACAP/PAC1 regulation in cystitis rats: induction of bladder inflammation cascade leading to bladder dysfunction [PDF]

Frontiers in Immunology
IntroductionInterstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a chronic and debilitating condition marked by bladder pain, urinary urgency, and frequency.
Hanwei Ke, Hanwei Ke, Lin Zhu, Weiyu Zhang, Weiyu Zhang, Huanrui Wang, Huanrui Wang, Zehua Ding, Zehua Ding, Dongyu Su, Dongyu Su, Qi Wang, Qi Wang, Kexin Xu, Kexin Xu   +14 more
doaj   +2 more sources

Impact of N-linked glycans on the dual short fibulin/LTBP-4 axes regulating elastogenesis. [PDF]

FEBS J
Elastic fiber assembly is orchestrated by multiple glycoproteins. We delineate the molecular basis of two key axes involved in elastic fiber formation—LTBP‐4L/fibulin‐4 and LTBP‐4S/fibulin‐5. We show that N‐linked glycans on these glycoproteins regulate their interactions and conformations, both of which are critical aspects in elastic fiber formation.
Nelea V, Kumra H, Lee CS, Williamson D, Hakami H, Zhang RM, Dinesh NEH, Haltiwanger R, Reinhardt DP.   +8 more
europepmc   +2 more sources

PAC1 constrains type 2 inflammation through promotion of CGRP signaling in ILC2s [PDF]

The Journal of Clinical Investigation
Dysfunction of group 2 innate lymphoid cells (ILC2s) plays an important role in the development of type 2 inflammation–related diseases such as asthma and pulmonary fibrosis.
Yuan Jin, Bowen Liu, Qiuyu Li, Xiangyan Meng, Xiaowei Tang, Yan Jin, Yuxin Yin   +6 more
doaj   +2 more sources

Structural basis of human 20S proteasome biogenesis [PDF]

Nature Communications
New proteasomes are produced to accommodate increases in cellular catabolic demand and prevent the accumulation of cytotoxic proteins. Formation of the proteasomal 20S core complex relies on the function of the five chaperones PAC1-4 and POMP.
Hanxiao Zhang, Chenyu Zhou, Zarith Mohammad, Jianhua Zhao   +3 more
doaj   +2 more sources

Development and pharmacological characterization of novel multi- calcitonin gene-related peptide and pituitary adenylate cyclase-activating peptide receptor antagonists. [PDF]

Headache
Abstract Objective This study aimed to provide proof‐of‐concept that multi‐receptor antagonist peptides can be generated by covalently linking independent antagonist peptides that block calcitonin gene‐related peptide (CGRP8‐37) or pituitary adenylate cyclase‐activating peptide (PACAP)/vasoactive intestinal peptide (VIP) (PACAP6‐38) activity ...
Tasma Z, Siow A, Harris PWR, Brimble MA, Hay DL, Walker CS.   +5 more
europepmc   +2 more sources

VPAC1 and VPAC2 receptors mediate tactile hindpaw hypersensitivity and carotid artery dilatation induced by PACAP38 in a migraine relevant mouse model [PDF]

The Journal of Headache and Pain
Background Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide pivotal in migraine pathophysiology and is considered a promising new migraine drug target.
Song Guo, Rikke Holm Rasmussen, Anders Hay-Schmidt, Messoud Ashina, Ayodeji A. Asuni, Jeppe Møller Jensen, Anja Holm, Sabrina Prehn Lauritzen, Glenn Dorsam, Jens Hannibal, Birgitte Georg, David Møbjerg Kristensen, Jes Olesen, Sarah Louise Christensen   +13 more
doaj   +2 more sources

Positive allosteric regulation of PAC1-R up-regulatesPAC1-R and its specific ligand PACAP

Acta Biochimica et Biophysica Sinica, 2022
PAC1-R is a recognized preferential receptor for the neuropeptide of pituitary adenylate cyclase-activating polypeptide (PACAP), which mediates neuroprotective and nerve regenerative activities of PACAP.
Fan Guangchun, Tao Zhengxin, Chen Shang, Zhang Huahua, Yu Rongjie   +4 more
doaj   +1 more source

A novel small positive allosteric modulator of neuropeptide receptor PAC1-R exerts neuroprotective effects in MPTP mouse Parkinson’s disease model

Acta Biochimica et Biophysica Sinica, 2022
As a neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP)-preferring receptor, PAC1-R mediates effective neuroprotective activity.
Fan Guangchun, Chen Shang, Tao Zhengxin, Zhang Huahua, Yu Rongjie   +4 more
doaj   +1 more source