Results 131 to 140 of about 4,096 (155)

PAC1-ing up the epigenetic landscape

Nature Immunology, 2020
Oxidative stress in the tumor microenvironment activates expression of the phosphatase PAC1 in infiltrated T lymphocytes. PAC1 regulates the epigenetic modulator NuRD to limit the chromatin accessibility of T cell effector function genes, thereby fostering T cell exhaustion.
Sze Chun Leo, Chan, Yongliang, Zhang
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Calcitonin/PAC1 receptor splice variants

Trends in pharmacological sciences, 2023
The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide (PACAP) and their receptors are linked to migraine neurobiology. Recent antimigraine therapeutics targeting the signaling of these neuropeptides are effective; however, some patients respond suboptimally, indicating an incomplete ...
Rees, Tayla A, Labastida-Ramírez, Alejandro, Rubio-Beltrán, Eloisa   +2 more
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PAC1 Receptor

Annals of the New York Academy of Sciences, 2006
Abstract: Septic shock is a systemic response to severe bacterial infections, generally caused by Gram‐negative bacterial endotoxins, with multiple manifestations such as hypotension, tissue injury, disseminated intravascular coagulation, and multi‐organ failure.
Carmen, Martínez, Alicia, Arranz, Yasmina, Juarranz, Catalina, Abad, María, García-Gómez, Florencia, Rosignoli, Javier, Leceta, Rosa P, Gomariz   +7 more
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PAC1-expressing structures of neural retina alter their PAC1 isoform splicing during postnatal development

Cell and Tissue Research, 2013
Pituitary adenylate cyclase-activating polypeptide (PACAP), a member of the secretin/glucagon/vasoactive intestinal peptide family, exerts various effects on neuronal development as mediated by the differential expression of PAC1 receptor (PAC1-R) isoforms.
V, Dénes, N, Czotter, M, Lakk, G, Berta, R, Gábriel   +4 more
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Maxadilan, the PAC1 Receptor, and Leishmaniasis

Journal of Molecular Neuroscience, 2008
Maxadilan is a vasodilator peptide isolated from sand fly salivary glands. The vasodilator effects of maxadilan are mediated by the PAC1 receptor, although maxadilan and PACAP do not share sequence homology. Sand flies are the vector of the parasitic disease leishmaniasis.
Vemuri B, Reddy, Yhong, Li, Ethan A, Lerner   +2 more
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Pac1 Ribonuclease of Schizosaccharomyces pombe

2001
Publisher Summary The Pac1 RNase of the fission yeast Schizosaccharomyces pombe is a doublestrand-specific endoribonuclease (dsRNase) whose structure, biochemical properties, and biological functions place it in the RNase III family. This chapter describes the methods that have been used to define the biological functions and biochemical properties ...
G, Rotondo, D, Frendewey
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Characterization of four receptor cDNAs: PAC1, VPAC1, a novel PAC1 and a partial GHRH in zebrafish

Molecular and Cellular Endocrinology, 2005
To understand the role of growth hormone-releasing hormone (GHRH) and pituitary adenylate cyclase-activating polypeptide (PACAP) and to examine the functional significance of the co-expression of GHRH and PACAP in fish, their receptors were characterized in zebrafish.
Erica A, Fradinger, Javier A, Tello, Jean E, Rivier, Nancy M, Sherwood   +3 more
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The functional recombinant first extracellular (EC1) domain of PACAP receptor PAC1 normal form (PAC1-EC1(N)) recognizes selective ligands and stimulates the proliferation of PAC1-CHO cells

Neuroscience Letters, 2010
PAC1 is a pituitary adenylate cyclase-activating polypeptide (PACAP) preferring receptor, which is abundant in the central and peripheral nervous systems. PAC1 belongs to the class B family of G protein-coupled receptors (GPCRs). The N-terminal first extracellular (EC1) domain of PAC1 is responsible for ligand recognition and binding.
Rongjie, Yu, Juan, Li, Jingjing, Wang, Xiaofei, Liu, Lin, Huang, Yong, Ding, Jiansu, Chen   +6 more
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