Results 141 to 150 of about 4,096 (155)

Granule Cell Survival is Deficient in PAC1−/− Mutant Cerebellum

Journal of Molecular Neuroscience, 2008
PACAP exerts neuroprotective effects during development, especially in the cerebellum where PAC1 receptor and ligand are both expressed. However, while previous studies using PACAP injections in postnatal animals defined trophic effects of exogenous peptide, the role of endogenous PACAP remains unexplored.
Falluel-Morel, Anthony, Tascau, Liana, Sokolowski, Katie, Brabet, Philippe, Dicicco-Bloom, Emanuel   +4 more
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Maxadilan Activates PAC1 Receptors Expressed in Xenopus laevis Melanophores

Pigment Cell Research, 2002
Functional interactions between ligands and their cognate receptors can be investigated using the ability of melanophores from Xenopus laevis to disperse or aggregate their pigment granules in response to alterations in the intracellular levels of second messengers.
Phyllis, Pereira, Vermuri B, Reddy, Kounga, Kounga, Ysabel, Bello, Ethan, Lerner   +4 more
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Expression of PAC1 receptor in rat thymus after irradiation

Regulatory Peptides, 2004
In the present work, PAC1-R (G-protein-coupled receptor specific for PACAP) was detected on cells in the normal thymus. Immunohistochemically PAC1-R was expressed strongly in stromal cells of the thymic medulla. Positive cells were also observed in the thymus of fetal and old adult rats.
Nobuko, Tokuda, Keiko, Hamasaki, Noriko, Mizutani, Yasuhiro, Adachi, Tomoo, Sawada, Hisayuki, Funahashi, Seiji, Shioda, Tetsuo, Fukumoto   +7 more
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PACAP and PAC1 receptor in brain development and behavior

Neuropeptides, 2013
Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) act through three class B G-protein coupled receptors, PAC1, VPAC1 and VPAC2, initiating multiple signaling pathways. In addition to natural peptides ligands, a number of synthetic peptides and a small molecular antagonist have been generated. Genetically
Sanbing, Shen, Donald R, Gehlert, David A, Collier   +2 more
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Characterization of the Replicon from Plasmid pAC1 from Acetobacter pasteurianus

Biochemical and Biophysical Research Communications, 1993
A panel of recombinant plasmids pACK5 and pACT7 was prepared by introducing kanamycin and tetracycline resistance into the partially split plasmid pAC1 which contained replicon isolated from Acetobacter pasteurianus. The replicon in plasmid pAC1 is compatible with the ColE1 replicon.
J, Grones, A, Králová, J, Turna
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Characterization of the PAC1 Variants Expressed in the Mouse Heart

Annals of the New York Academy of Sciences, 2006
Abstract: Pituitary adenylate cyclase‐activating polypeptide (PACAP), a pleiotropic neuropeptide, exerts a variety of physiological functions through three types of G protein–coupled receptors, PAC1, VPAC1, and VAPC2. Characterization of the molecular forms of PAC1 in mouse heart revealed the presence of four types of variant receptors harboring the N ...
Mina, Ushiyama, Hideki, Sugawara, Kazuhiko, Inoue, Kenji, Kangawa, Katsushi, Yamada, Atsuro, Miyata   +5 more
openaire   +2 more sources

Novel stable PACAP analogs with potent activity towards the PAC1 receptor

Peptides, 2008
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 38- or 27-amino acid neuropeptide with promising therapeutic applications for the treatment of several pathophysiological states related to neurodegenerative diseases. However, its use for therapeutic applications is actually limited by its restricted bioavailability and rapid degradation.
Steve, Bourgault, David, Vaudry, Béatrice, Botia, Alain, Couvineau, Marc, Laburthe, Hubert, Vaudry, Alain, Fournier   +6 more
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pH and Pac1 control development and antifungal activity in Trichoderma harzianum

Fungal Genetics and Biology, 2007
In Trichoderma harzianum CECT 2413 external pH regulates essential functions such as growth rate, sporulation, cell and colony morphology, pattern of secreted proteins, gene expression or mycoparasitism-related enzymatic activities. pH regulation is mediated by the transcriptional factor Pac1 (homologous to PacC regulator in other fungi), encoded by ...
Miguel A, Moreno-Mateos, Jesús, Delgado-Jarana, Antonio C, Codón, Tahía, Benítez   +3 more
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PACAP Receptor (PAC1‐R) Expression in Rat and Rhesus Monkey Thymus

Annals of the New York Academy of Sciences, 2006
Abstract: The expression of PACAP receptor (PAC1‐R) was investigated in the thymus of rats and rhesus monkeys. In the rat thymus, PAC1‐R positive cells were found in the intermediate type of thymic epithelial cells of the medulla. PAC1‐R‐positive cells were also seen in the thymic medulla of the rhesus monkey.
N, Tokuda, Y, Arudchelvan, T, Sawada, Y, Adachi, T, Fukumoto, M, Yasuda, H, Sumida, S, Shioda, T, Fukuda, A, Arima, S, Kubota   +10 more
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Ontogeny of PAC1-R and VPAC1-R in the frog, Rana esculenta

Peptides, 2007
The distribution of pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP receptors in the brain of amphibians has been previously described. In the present study, we have investigated the ontogeny of the selective PACAP receptor, PAC1-R, and the PACAP-vasoactive intestinal polypeptide (VIP) mutual receptor, VPAC1-R, in frog embryos by ...
M. CIARLO, F. BRUZZONE, ANGELINI, CRISTIANO, VALLARINO, MAURO, H. VAUDRY   +4 more
openaire   +3 more sources