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Performance of PAC1-R Heterozygous Mice in Memory Tasks-II
Journal of Molecular Neuroscience, 2008An involvement of pituitary adenylate cyclase activating polypeptide-specific receptor type 1 (PAC1-R) in behavioral performance of retrieval of memory upon the stimulation of perception of sensory modality was investigated in mice. Eighteen heterozygous (-/+) transgenic mutant PAC1-R-deficient mice ((-/+) mice) and 18 wild-type (+/+) mice of ...
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Strategy for the development of small-molecule antidepressant targeting PAC1 receptor
Folia Pharmacologica JaponicaMajor depressive disorder (MDD) is a psychiatric disorder that affects more than 300 million people worldwide and has a serious impact on society. Conventional antidepressants targeting monoamines in the brain based on the monoamine hypothesis are known to take a prolonged time to be effective or less effective in 30% of MDD patients. Hence, there is a
Ichiro, Takasaki +4 more
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LIS1 (Pac1) binding slows dissociation of dynein from microtubules
Nature Chemical Biology, 2023openaire +2 more sources
Biologically active PAC1 receptor isoform in human neoplastic prostate
2001C. MAMM +4 more
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