Results 11 to 20 of about 4,096 (155)
Breeding of virus-resistant transgenic sugarcane by the integration of the Pac1 gene [PDF]
Frontiers in Sustainable Food Systems, 2022 Various RNA viral diseases on sugarcane result in yield loss and decreased sugar content. Breeding new varieties with virus resistance is the main goal of the sugarcane breeding program.
Wenzhi Wang +9 more
doaj +3 more sources
PACAP–PAC1 Signaling Regulates Serotonin 2A Receptor Internalization [PDF]
Frontiers in Endocrinology, 2021 Mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP) display psychomotor abnormalities, most of which are ameliorated by atypical antipsychotics with serotonin (5-HT) 2A receptor (5-HT2A) antagonism. Heterozygous Pacap mutant mice show
Atsuko Hayata-Takano +12 more
doaj +3 more sources
The PACAP/PAC1 Receptor System and Feeding [PDF]
Brain Sciences, 2021 Pituitary adenylyl cyclase activating polypeptide (PACAP) belongs to the vasoactive intestinal polypeptide (VIP)/secretin/glucagon superfamily. PACAP is present in two forms (PACAP-38 and PACAP-27) and binds to three guanine-regulatory (G) protein-coupled receptors (PAC1, VPAC1, and VPAC2).
Keerthana Sureshkumar +3 more
openaire +6 more sources
Altered Circadian Food Anticipatory Activity Rhythms in PACAP Receptor 1 (PAC1) Deficient Mice. [PDF]
PLoS ONE, 2016 Light signals from intrinsically photosensitive retinal ganglion cells (ipRGCs) entrain the circadian clock and regulate negative masking. Two neurotransmitters, glutamate and Pituitary Adenylate Cyclase Activating Polypeptide (PACAP), found in the ...
Jens Hannibal +2 more
doaj +1 more source
PAC1 Receptors: Shapeshifters in Motion [PDF]
Journal of Molecular Neuroscience, 2018 Shapeshifters, in common mythology, are entities that can undergo multiple physical transformations. As our understanding of G protein-coupled receptors (GPCRs) has accelerated and been refined over the last two decades, we now understand that GPCRs are not static proteins, but rather dynamic structures capable of moving from one posture to the next ...
Chenyi Liao, Victor May, Jianing Li
openaire +2 more sources
Neuroendocrine Tumors Express PAC1 Receptors [PDF]
Annals of the New York Academy of Sciences, 2006 Abstract: Neuroendocrine tumors (NETs) of the gastrointestinal tract can be grossly divided into two general types: carcinoid and pancreatic endocrine tumors. The former develop in the luminal intestine whereas the latter occur within the pancreas. To ascertain whether pituitary adenylate cyclase‐activating polypeptide (PACAP) has a biological effect ...
Song N, Lieu +3 more
openaire +2 more sources
Neurobiology of Disease, 2021 Chronic inflammation drives synaptic loss in multiple sclerosis (MS) and is also commonly observed in other neurodegenerative diseases. Clinically approved treatments for MS provide symptomatic relief but fail to halt neurodegeneration and neurological ...
Christina Van +11 more
doaj +1 more source
The N-terminal HSDCIF motif is required for cell surface trafficking and dimerization of family B G protein coupled receptor PAC1. [PDF]
PLoS ONE, 2012 PAC1 is PACAP (pituitary adenylate cyclase-activating polypeptide) preferring receptor belonging to class B G protein coupled receptor (GPCR) mediating the most effects of PACAP.
Rongjie Yu +5 more
doaj +1 more source
PACAP and PAC1 Receptor Expression in Human Insulinomas [PDF]
International Journal of Peptide Research and Therapeutics, 2021 AbstractPituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide with widespread occurrence and diverse functions. PACAP binds to specific PAC1 and non-specific VPAC1/2 receptors. PACAP is considered as a growth factor, as it plays important roles during development and participates in reparative processes.
Ferencz, Sándor +7 more
openaire +2 more sources
Preclinical evaluation of PAC1 targeting with radiolabeled Maxadilan [PDF]
Scientific Reports, 2017 AbstractThere is an ongoing search for new tracers to optimize imaging of beta cell-derived tumors (insulinomas). The PAC1 receptor, expressed by insulinomas, can be used for targeting of these tumors. Here, we investigated whether radiolabeled maxadilan could be used for insulinoma imaging. Maxadilan was C- or N-terminally conjugated with DTPA (termed
Lieke Joosten +5 more
openaire +6 more sources