Results 21 to 30 of about 4,096 (155)

PAC1- and VPAC2 receptors in light regulated behavior and physiology: Studies in single and double mutant mice. [PDF]

PLoS ONE, 2017
The two sister peptides, pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) and their receptors, the PAC1 -and the VPAC2 receptors, are involved in regulation of the circadian timing system.
Jens Hannibal, Birgitte Georg, Jan Fahrenkrug   +2 more
doaj   +1 more source

Activation of the PACAP/PAC1 Signaling Pathway Accelerates the Repair of Impaired Spatial Memory Caused by an Ultradian Light Cycle

ASN Neuro, 2023
The mechanism of light-induced spatial memory deficits, as well as whether rhythmic expression of the pituitary adenylyl cyclase-activating polypeptides (PACAP)-PAC1 pathway influenced by light is related to this process, remains unclear.
Dejiao Xu, Ying Zhang, Jun Feng, Hongyu Fu, Jiayi Li, Wei Wang, Zhen Li, Pingping Zhang, Xinqi Cheng, Liecheng Wang, Juan Cheng   +10 more
doaj   +1 more source

Sexually dimorphic role of the locus coeruleus PAC1 receptors in regulating acute stress-associated energy metabolism

Frontiers in Behavioral Neuroscience, 2022
Severe stress leads to alterations in energy metabolism with sexually dimorphic onset or severity. The locus coeruleus (LC) in the brainstem that mediates fight-or-flight-or-freeze response to stress is sexually dimorphic in morphology, plays a key role ...
Samuel J. Duesman, Sanutha Shetty, Sanil Patel, Neha Ogale, Farzanna Mohamed, Njeri Sparman, Prashant Rajbhandari, Abha Karki Rajbhandari   +7 more
doaj   +1 more source

Distribution of PACAP and PAC1 Receptor in the Human Eye [PDF]

Journal of Molecular Neuroscience, 2022
Abstract Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide with widespread distribution and diverse biological functions. Several studies show that PACAP has strong cytoprotective effects mediated mostly through its specific PAC1 receptor (PAC1-R) and it plays important roles in several pathological conditions.
Evelin Patko, Edina Szabo, Denes Toth, Tamas Tornoczky, Inez Bosnyak, Alexandra Vaczy, Tamas Atlasz, Dora Reglodi   +7 more
openaire   +4 more sources

Doxycycline and Minocycline Act as Positive Allosteric Modulators of the PAC1 Receptor and Induce Plasminogen Activators in RT4 Schwann Cells

Applied Sciences, 2021
Regeneration of peripheral nerves depends on the ability of axons to navigate through an altered extracellular environment. It has been suggested that Schwann cells facilitate this process through their secretion of neuropeptides and proteases. Using the
Sarah Thomas Broome, Giuseppe Musumeci, Alessandro Castorina   +2 more
doaj   +1 more source

PACAP/PAC1 Expression and Function in Micturition Pathways [PDF]

Journal of Molecular Neuroscience, 2018
Neural injury, inflammation, or diseases commonly and adversely affect micturition reflex function that is organized by neural circuits in the CNS and PNS. One neuropeptide receptor system, pituitary adenylate cyclase-activating polypeptide (PACAP; Adcyap1), and its cognate receptor, PAC1 (Adcyap1r1), have tissue-specific distributions in the lower ...
Jacqueline Ojala, Katharine Tooke, Harrison Hsiang, Beatrice M. Girard, Victor May, Margaret A. Vizzard   +5 more
openaire   +2 more sources

Dimer-dependent intrinsic/basal activity of the class B G protein-coupled receptor PAC1 promotes cellular anti-apoptotic activity through Wnt/β-catenin pathways that are associated with dimer endocytosis.

PLoS ONE, 2014
The high expression of PACAP (pituitary adenylate cyclase-activating polypeptide)-preferring receptor PAC1 is associated with nerve injury and tumors. Our previous report (Yu R, et al.
Rongjie Yu, Zekai Cui, Mei Li, Yanxu Yang, Jiaping Zhong   +4 more
doaj   +1 more source

Maxadilan, a PAC1 receptor agonist from sand flies [PDF]

Peptides, 2007
In 1991, a potent 61 amino acid vasodilator peptide, named maxadilan, was isolated from the salivary glands of the sand fly. Subsequently, it was shown that this peptide specifically and potently activated the mammalian PAC1 receptor, one of the three receptors for PACAP. These studies and the link between maxadilan and leishmaniasis are discussed.
Ethan A, Lerner, Aurel O, Iuga, Vemuri B, Reddy   +2 more
openaire   +2 more sources

Secreted key regulators (Fgf1, Bmp4, Gdf3) are expressed by PAC1-immunopositive retinal ganglion cells in the postnatal rat retina

European Journal of Histochemistry, 2022
Identified as a member of the secretin/glucagon/VIP superfamily, pituitary adenylate cyclase-activating polypeptide (PACAP1-38) has been recognized as a hormone, neurohormone, transmitter, trophic factor, and known to be involved in diverse and multiple
Viktória Dénes, Kármen Kovacs, Ákos Lukáts, Adrienn Mester, Gergely Berta, Arnold Szabó, Robert Gabriel   +6 more
doaj   +1 more source

PAC1 Receptor Mediates Electroacupuncture-Induced Neuro and Immune Protection During Cisplatin Chemotherapy

Frontiers in Immunology, 2021
Platinum-based chemotherapy is an effective treatment used in multiple tumor treatments, but produces severe side effects including neurotoxicity, anemia, and immunosuppression, which limits its anti-tumor efficacy and increases the risk of infections ...
Shanshan Li, Jin Huang, Yi Guo, Yi Guo, Yi Guo, Jiaqi Wang, Shanshan Lu, Bin Wang, Yinan Gong, Siru Qin, Suhong Zhao, Shenjun Wang, Shenjun Wang, Shenjun Wang, Yangyang Liu, Yangyang Liu, Yangyang Liu, Yuxin Fang, Yuxin Fang, Yuxin Fang, Yongming Guo, Yongming Guo, Yongming Guo, Zhifang Xu, Zhifang Xu, Zhifang Xu, Luis Ulloa   +26 more
doaj   +1 more source