Results 31 to 40 of about 4,096 (155)
Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism [PDF]
Cell Research, 2020 AbstractThe pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1R) belongs to the secretin receptor family and is widely distributed in the central neural system and peripheral organs. Abnormal activation of the receptor mediates trigeminovascular activation and sensitization, which is highly related to migraine, making PAC1R a ...
Jia Wang +16 more
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Scientific Reports, 2023 Cryopreservation of platelets, at − 80 °C with 5–6% DMSO, results in externalisation of phosphatidylserine and the formation of extracellular vesicles (EVs), which may mediate their procoagulant function.
Lacey Johnson +4 more
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Cyclical depressurization degranulates platelets in an agonist-free mechanism of platelet activation
PLoS ONE, 2022 Activation of circulating platelets by receptor binding and subsequent coagulation events are defined by a well characterized physiological response. However, the growing prevalence of chronic kidney disease (CKD) and implication of platelet-released ...
Aaron J. Velasquez-Mao +2 more
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The Sclerotinia sclerotiorum pac1 Gene Is Required for Sclerotial Development and Virulence
Molecular Plant-Microbe Interactions, 2003 The synergistic activities of oxalic acid and endopolygalacturonases are thought to be essential for full virulence of Sclerotinia sclerotiorum and other oxalate-producing plant pathogens.
Jeffrey A. Rollins
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Maxadilan prevents apoptosis in iPS cells and shows no effects on the pluripotent state or karyotype. [PDF]
PLoS ONE, 2012 Pituitary adenylate cyclase-activating polypeptide (PACAP) is a structurally endogenous peptide with many biological roles. Maxadilan, a 61-amino acid vasodilatory peptide, specifically activates the PACAP type I receptor (PAC1).
Zhiyi Zhao +6 more
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Frontiers in Cellular Neuroscience, 2021 Pituitary adenylyl cyclase-activating polypeptide (PACAP) is a member of the vasoactive intestinal polypeptide (VIP)-the secretin-glucagon family of neuropeptides. They act through two classes of receptors: PACAP type 1 (PAC1) and type 2 (VPAC1 and VPAC2)
Jérôme Ruel +8 more
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BMC Cardiovascular Disorders, 2023 Background Induction of chondrogenesis is associated with progressive atherosclerosis. Deficiency of the ADCYAP1 gene encoding pituitary adenylate cyclase-activating peptide (PACAP) aggravates atherosclerosis in ApoE deficient (ApoE−/−) mice.
C. Blümm +5 more
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Neurobiology of Disease, 2017 Pituitary adenylate cyclase activating polypeptide (PACAP) and its complementary receptor, PAC1, are crucial in central respiratory control. PACAP Knockout (KO) mice exhibit a SIDS-like phenotype, with an inability to overcome noxious insults ...
J. Huang, K.A. Waters, R. Machaalani
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Pituitary adenylate cyclase activating polypeptide (PACAP) signalling exerts chondrogenesis promoting and protecting effects: implication of calcineurin as a downstream target. [PDF]
PLoS ONE, 2014 Pituitary adenylate cyclase activating polypeptide (PACAP) is an important neurotrophic factor influencing differentiation of neuronal elements and exerting protecting role during traumatic injuries or inflammatory processes of the central nervous system.
Tamás Juhász +11 more
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Protective effects of PACAP in ischemia
The Journal of Headache and Pain, 2018 Pituitary adenylate cyclase activating polypeptide (PACAP) is an ubiquitous peptide involved, among others, in neurodevelopment, neuromodulation, neuroprotection, neurogenic inflammation and nociception. Presence of PACAP and its specific receptor, PAC1,
Dora Reglodi +3 more
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