Results 41 to 50 of about 4,096 (155)
iScience, 2023 Summary: Opioids prescribed for pain and migraine can produce opioid-induced hyperalgesia (OIH) or medication overuse headache (MOH). We previously demonstrated that pituitary adenylate cyclase activating polypeptide (PACAP) is upregulated in OIH and ...
Zachariah Bertels +5 more
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Regulation of myoepithelial differentiation.
PLoS ONE, 2022 The salivary gland can be permanently impaired by radiation treatment for head and neck cancers. Efforts at tissue regeneration have focused on saliva-producing acinar cells.
Renee F Thiemann +5 more
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European Journal of Histochemistry, 2022 Pituitary adenylate cyclase-activating polypeptide (PACAP) plays an important role in the steroidogenesis and spermatogenesis in the testis through its receptors PAC1, VPAC1, and VPAC2.
Zeqi Tang +7 more
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Positive allosteric regulation of PAC1-R up-regulates PAC1-R and its specific ligand PACAP.
Acta biochimica et biophysica Sinica, 2022 PAC1-R is a recognized preferential receptor for the neuropeptide of pituitary adenylate cyclase-activating polypeptide (PACAP), which mediates neuroprotective and nerve regenerative activities of PACAP. In this study, we found that in both PAC1R-CHO cells with high expression of PAC1R-eGFP and retinal ganglion cells (RGC-5) with the natural expression
Fan Guangchun +4 more
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Purification and Characterization of the Pac1 Ribonuclease of Schizosaccharomyces Pombe [PDF]
Nucleic Acids Research, 1996 The pac1+ gene of the fission yeast Schizosaccharomyces pombe is essential for viability and its overexpression induces sterility and suppresses mutations in the pat1+ and snm1+ genes. The pac1+ gene encodes a protein that is structurally similar to RNase III from Escherichia coli, but its normal function is unknown. We report here the purification and
G, Rotondo, D, Frendewey
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PACAP-38 and PACAP(6–38) Degranulate Rat Meningeal Mast Cells via the Orphan MrgB3-Receptor
Frontiers in Cellular Neuroscience, 2019 Infusion of pituitary adenylate cyclase activating peptide-38 (PACAP-38) provokes migraine attacks in migraineurs and headache in non-migraineurs. Adverse events like long-lasting flushing and heat sensation can be terminated with oral antihistamine ...
Sara Hougaard Pedersen +10 more
doaj +1 more source
Frontiers in Psychiatry, 2022 Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide with isoforms consisting of either 27 or 38 amino acids. PACAP is encoded by the adenylate cyclase activating peptide gene, ADCYAP1, in humans and the highly conserved ...
Manessa Riser, Seth Davin Norrholm
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PACAP and the PAC1 Receptor in Post-Traumatic Stress Disorder [PDF]
Neuropsychopharmacology, 2012 Post-traumatic stress disorder (PTSD) affects approximately 5–10% of all individuals and is more predominant in women (Breslau, 2001). Advances in treatment and prevention will require identifying biomarkers to aid early diagnosis and understanding the mechanisms underlying maladaptive responses to trauma.
Brian G, Dias, Kerry J, Ressler
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Targeting the PAC1 Receptor for Neurological and Metabolic Disorders
Current Topics in Medicinal Chemistry, 2019 The pituitary adenylate cyclase-activating polypeptide (PACAP)-selective PAC1 receptor (PAC1R, ADCYAP1R1) is a member of the vasoactive intestinal peptide (VIP)/secretin/glucagon family of G protein-coupled receptors (GPCRs). PAC1R has been shown to play crucial roles in the central and peripheral nervous systems.
Liao, Chenyi +8 more
openaire +4 more sources
Improved platelet recovery in cryopreserved platelets reconstituted in freeze‐dried plasma
Transfusion, EarlyView.Abstract Background Cryopreserved platelets can support availability in settings where fresh platelets are inaccessible. Freeze‐dried plasma (FDP) may serve as an alternative reconstitution medium to fresh frozen plasma (FFP) when plasma thawing is impractical. The effects of FDP on cryopreserved platelet quality remain underexplored. Thus, we aimed to
Kristina Ehn +3 more
wiley +1 more source