Results 51 to 60 of about 4,096 (155)

PACAP and PAC1 receptor expression in pancreatic ductal carcinoma

Oncology Letters, 2019
Pancreatic carcinoma is one of the most malignant diseases and is associated with a poor survival rate. Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide that acts on three different G protein-coupled receptors: the specific PAC1 and the VPAC1/2 that also bind vasoactive intestinal peptide.
Ferencz, Sandor, Reglodi, Dora, Kaszas, Balint, Bardosi, Attila, Toth, Denes, Vekony, Zsofia, Vicena, Viktoria, Karadi, Oszkar, Kelemen, Dezso   +8 more
openaire   +3 more sources

Pituitary adenylate cyclase-activating polypeptide type 1 receptor signaling evokes long-lasting nociceptive behaviors through the activation of spinal astrocytes in mice

Journal of Pharmacological Sciences, 2016
Intrathecal (i.t.) administration of pituitary adenylate cyclase-activating polypeptide (PACAP) induces long-lasting nociceptive behaviors for more than 60 min in mice, while the involvement of PACAP type1 receptor (PAC1-R) has not been clarified yet ...
Tetsuya Ohnou, Masafumi Yokai, Takashi Kurihara, Maiko Hasegawa-Moriyama, Takao Shimizu, Kazuhiko Inoue, Yuki Kambe, Yuichi Kanmura, Atsuro Miyata   +8 more
doaj   +1 more source

Increased pituitary adenylate cyclase-activating peptide genes expression in the prefrontal cortex in schizophrenia in relation to suicide

Frontiers in Molecular Neuroscience, 2023
IntroductionPituitary adenylate cyclase-activating peptide (PACAP) is a stress-related neuropeptide that is produced in several brain areas. It acts by 3 receptors: PACAP type-1 (PAC1), vasoactive intestinal peptide (VIP) -1 and -2 (VPAC1 and 2). Data on
Zala Slabe, Zala Slabe, Rawien A. Balesar, Ronald W. H. Verwer, Gorazd Drevenšek, Dick F. Swaab, Dick F. Swaab   +6 more
doaj   +1 more source

PAC1 receptor modulation of freezing and flight behavior in periaqueductal gray

Genes, Brain and Behavior, 2023
AbstractThe midbrain periaqueductal gray (PAG) region is a critical anatomical regulator of fear‐related species‐specific defensive reactions (SSDRs). Pituitary adenylate‐cyclase‐activating polypeptide (PACAP), and its main receptor PAC1, play an important role in fear‐related behavior and anxiety disorders.
Ersin Yavas, Irina Zhuravka, Michael S. Fanselow   +2 more
openaire   +3 more sources

Macrophage Resistance to HIV-1 Infection Is Enhanced by the Neuropeptides VIP and PACAP. [PDF]

PLoS ONE, 2013
It is well established that host factors can modulate HIV-1 replication in macrophages, critical cells in the pathogenesis of HIV-1 infection due to their ability to continuously produce virus.
Jairo R Temerozo, Rafael Joaquim, Eduardo G Regis, Wilson Savino, Dumith Chequer Bou-Habib   +4 more
doaj   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, Volume 12, Issue 1, Page 65-85, Spring 2026.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

The Role of Extracellular Vesicles in Transient Ischaemic Attacks and Ischaemic Stroke: A Systematic Review

Journal of Extracellular Biology, Volume 5, Issue 3, March 2026.
Both transient ischaemic attack (TIA) and ischaemic stroke lead to an increase in individual cellular‐derived populations of extracellular vesicles (EVs), including endothelial, platelet and leukocyte derived. These EVs have downstream roles in the pathophysiological events associated with TIA and stroke, including dysregulated inflammation and ...
Rebecca Marie Raven, Philip Eurig James, Keith Morris, Jessica Olivia Williams   +3 more
wiley   +1 more source

iRhom1 regulates proteasome activity via PAC1/2 under ER stress [PDF]

Scientific Reports, 2015
AbstractProteasome is a protein degradation complex that plays a major role in maintaining cellular homeostasis. Despite extensive efforts to identify protein substrates that are degraded through ubiquitination, the regulation of proteasome activity itself under diverse signals is poorly understood.
Lee, WonJae, Kim, YoungDoo, Park, Jisu, Shim, SangMi, Lee, Jieun, Hong, Se-hoon, Ahn, Hye-Hyun, Lee, Huikyong, Jung, Yong-Keun   +8 more
openaire   +3 more sources

Cranberry Proanthocyanidins and Dietary Oligosaccharides Synergistically Modulate Lactobacillus plantarum Physiology

Microorganisms, 2021
Plant-based foods contain bioactive compounds such as polyphenols that resist digestion and potentially benefit the host through interactions with their resident microbiota. Based on previous observations, we hypothesized that the probiotic Lactobacillus
Ezgi Özcan, Michelle R. Rozycki, David A. Sela   +2 more
doaj   +1 more source

Neurons in a Dish: A Review of In Vitro Cell Models for Studying Neurogenesis

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
Different in vitro cell models are valuable to study the different steps of neurogenesis, from the proliferation of neural stem and progenitor cells to the maturation of neurons. Pluripotent stem cells (including embryonic stem cells and induced pluripotent stem cells), immortalized human neuroblastoma cell lines (SH‐SY5Y, IMR‐32), and primary brain ...
Mariana Vassal, Ana C. Cruz, Sandra Rebelo, Filipa Martins   +3 more
wiley   +1 more source