Results 61 to 70 of about 4,096 (155)
Frontiers in Endocrinology, 2013 Alternative splicing of the precursor mRNA encoding for the neuropeptide receptor PAC1/ADCYAP1R1 generates multiple protein products that exhibit pleiotropic activities.
Janna eBlechman, Gil eLevkowitz
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PACAP interacts with PAC1 receptors to induce tissue plasminogen activator (tPA) expression and activity in schwann cell-like cultures. [PDF]
PLoS ONE, 2015 Regeneration of peripheral nerves depends on the abilities of rejuvenating axons to migrate at the injury site through cellular debris and altered extracellular matrix, and then grow along the residual distal nerve sheath conduit and reinnervate synaptic
Alessandro Castorina +4 more
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, 2002 Zusammenfassung Im Rahmen dieser Arbeit wurde der PAC1-Rezeptor (Pituitary Adenylate Cyclase Activating-Polypeptide-Rezeptor), ein Mitglied der VIP-Glucagon-Rezeptorfamilie, aus Sf21-Insektenzellen angereichert. Zur Überexpression wurde das Baculovirussystem genutzt.
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Structures of human dynein in complex with the lissencephaly 1 protein, LIS1
eLife, 2023 The lissencephaly 1 protein, LIS1, is mutated in type-1 lissencephaly and is a key regulator of cytoplasmic dynein-1. At a molecular level, current models propose that LIS1 activates dynein by relieving its autoinhibited form.
Janice M Reimer +3 more
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The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors
British Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +206 more
wiley +1 more source
An archaeal homolog of proteasome assembly factor functions as a proteasome activator. [PDF]
PLoS ONE, 2013 Assembly of the eukaryotic 20S proteasome is an ordered process involving several proteins operating as proteasome assembly factors including PAC1-PAC2 but archaeal 20S proteasome subunits can spontaneously assemble into an active cylindrical ...
Kentaro Kumoi +9 more
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Frontiers in Neuroanatomy, 2022 Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are structurally related neuropeptides that are widely expressed in vertebrate tissues. The two neuropeptides are pleiotropic and have been associated with
Anne Marie Lund +3 more
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Synapse, Volume 79, Issue 6, November 2025.ABSTRACT Low‐dose ketamine is an efficacious antidepressant for treatment‐resistant unipolar and bipolar depressed patients. Major depressive disorder patients receiving a single infusion report elevated mood within 2 h, and ketamine's antidepressant effects have been observed as long as 7 days posttreatment.
Oliver H. Miller +5 more
wiley +1 more source
Neuronal PAC1 deletion impairs structural plasticity
Life SciencesAims: Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) is an endogenous neuropeptide of the central nervous system (CNS), whose biological activities are mediated via three G protein-coupled receptors PAC1, VPAC1, and VPAC2. While its neuroprotective functions are well-characterised, the role of PAC1 receptor-specific signalling in neuronal ...
Jansen, Margo I. +9 more
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In Silico Screening Identified Novel Small-molecule Antagonists of PAC1 Receptor [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2018 Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors are present in the spinal dorsal horn and dorsal root ganglia, suggesting an important role of PACAP signaling systems in the modulation of spinal nociceptive transmission. Previously, we found that intrathecal injection of PACAP or maxadilan, a selective PACAP type I (PAC1 ...
Ichiro, Takasaki +11 more
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