Results 1 to 10 of about 2,962 (109)

PAC1 Receptor Mediates Electroacupuncture-Induced Neuro and Immune Protection During Cisplatin Chemotherapy [PDF]

Frontiers in Immunology, 2021
Platinum-based chemotherapy is an effective treatment used in multiple tumor treatments, but produces severe side effects including neurotoxicity, anemia, and immunosuppression, which limits its anti-tumor efficacy and increases the risk of infections ...
Shanshan Li, Jin Huang, Yi Guo, Yi Guo, Yi Guo, Jiaqi Wang, Shanshan Lu, Bin Wang, Yinan Gong, Siru Qin, Suhong Zhao, Shenjun Wang, Shenjun Wang, Shenjun Wang, Yangyang Liu, Yangyang Liu, Yangyang Liu, Yuxin Fang, Yuxin Fang, Yuxin Fang, Yongming Guo, Yongming Guo, Yongming Guo, Zhifang Xu, Zhifang Xu, Zhifang Xu, Luis Ulloa   +26 more
doaj   +2 more sources

Spinal Astrocyte-Neuron Lactate Shuttle Contributes to the Pituitary Adenylate Cyclase-Activating Polypeptide/PAC1 Receptor-Induced Nociceptive Behaviors in Mice [PDF]

Biomolecules, 2022
We have previously shown that spinal pituitary adenylate cyclase-activating polypeptide (PACAP)/PACAP type 1 (PAC1) receptor signaling triggered long-lasting nociceptive behaviors through astroglial activation in mice.
Yuki Kambe, Masafumi Youkai, Kohei Hashiguchi, Yoshimune Sameshima, Ichiro Takasaki, Atsuro Miyata, Takashi Kurihara   +6 more
doaj   +2 more sources

PACAP-PAC1 receptor inhibition is effective in opioid induced hyperalgesia and medication overuse headache models [PDF]

iScience, 2023
Summary: Opioids prescribed for pain and migraine can produce opioid-induced hyperalgesia (OIH) or medication overuse headache (MOH). We previously demonstrated that pituitary adenylate cyclase activating polypeptide (PACAP) is upregulated in OIH and ...
Zachariah Bertels, Elizaveta Mangutov, Kendra Siegersma, Haley C. Cropper, Alycia Tipton, Amynah A. Pradhan   +5 more
doaj   +2 more sources

The role of pituitary adenylate cyclase-activating polypeptide neurons in the hypothalamic ventromedial nucleus and the cognate PAC1 receptor in the regulation of hedonic feeding [PDF]

Frontiers in Nutrition
Obesity is a health malady that affects mental, physical, and social health. Pathology includes chronic imbalance between energy intake and expenditure, likely facilitated by dysregulation of the mesolimbic dopamine (DA) pathway.
Sarah Sayers, Nikki Le, Edward J. Wagner
doaj   +2 more sources

The PACAP/PAC1 Receptor System and Feeding [PDF]

Brain Sciences, 2021
Pituitary adenylyl cyclase activating polypeptide (PACAP) belongs to the vasoactive intestinal polypeptide (VIP)/secretin/glucagon superfamily. PACAP is present in two forms (PACAP-38 and PACAP-27) and binds to three guanine-regulatory (G) protein ...
Keerthana Sureshkumar, Andrea Saenz, Syed M. Ahmad, Kabirullah Lutfy   +3 more
doaj   +2 more sources

First‐in‐human development of a pharmacodynamic biomarker for PAC1 receptor antagonists using intradermal injections of maxadilan [PDF]

Clinical and Translational Science, 2022
Maxadilan, a potent vasodilator peptide, selectively activates the PAC1 receptor, a promising target for migraine therapy. Therefore, maxadilan has been suggested as a tool to study the pharmacodynamics (PDs) of PAC1 receptor antagonists.
Heleen Marynissen, Linde Buntinx, Dorien Bamps, Marleen Depre, Els Ampe, Anne Van Hecken, Kristin Gabriel, Steve Sands, Gabriel Vargas, Jan de Hoon   +9 more
doaj   +2 more sources

Cardiac fibrosis induced by high-fat diet in ApoE-deficient male mice is exacerbated by genetic deletion of PACAP-PAC1 signaling. [PDF]

J Neuroendocrinol
Abstract Cardiac fibrosis is characterized by an excessive accumulation of extracellular matrix proteins and occurs in a variety of cardiac diseases, such as the highly prevalent syndrome heart failure with preserved ejection fraction (HFpEF) and other cardiac disorders.
Schubart JM, Schaefer MKH, Bonaterra GA, Mey L, Schwarzbach H, Pankuweit S, Ausbuettel F, Eiden LE, Weyand S, Weihe E, Kinscherf R, Waechter C.   +11 more
europepmc   +2 more sources

PACAP38 and PAC1 receptor blockade: a new target for headache? [PDF]

The Journal of Headache and Pain, 2018
Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) is a widely distributed neuropeptide involved in neuroprotection, neurodevelopment, nociception and inflammation.
Eloisa Rubio-Beltrán, Edvige Correnti, Marie Deen, Katharina Kamm, Tim Kelderman, Laura Papetti, Simone Vigneri, Antoinette MaassenVanDenBrink, Lars Edvinsson, On behalf of the European Headache Federation School of Advanced Studies (EHF-SAS)   +9 more
doaj   +2 more sources

The N-terminal HSDCIF motif is required for cell surface trafficking and dimerization of family B G protein coupled receptor PAC1. [PDF]

PLoS ONE, 2012
PAC1 is PACAP (pituitary adenylate cyclase-activating polypeptide) preferring receptor belonging to class B G protein coupled receptor (GPCR) mediating the most effects of PACAP.
Rongjie Yu, Xiaoling Guo, Jiaping Zhong, Mei Li, Zhixing Zeng, Huahua Zhang   +5 more
doaj   +1 more source

PAC1- and VPAC2 receptors in light regulated behavior and physiology: Studies in single and double mutant mice. [PDF]

PLoS ONE, 2017
The two sister peptides, pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) and their receptors, the PAC1 -and the VPAC2 receptors, are involved in regulation of the circadian timing system.
Jens Hannibal, Birgitte Georg, Jan Fahrenkrug   +2 more
doaj   +1 more source