Results 91 to 100 of about 3,032 (163)

PAC1 Receptor Internalization and Endosomal MEK/ERK Activation Is Essential for PACAP-Mediated Neuronal Excitability. [PDF]

J Mol Neurosci, 2021
May V, Johnson GC, Hammack SE, Braas KM, Parsons RL.   +4 more
europepmc   +1 more source

Investigation of the Role of Pituitary Adenylate Cyclase-Activating Peptide (PACAP) and Its Type 1 (PAC1) Receptor in Uterine Contractility during Endometritis in Pigs. [PDF]

Int J Mol Sci, 2022
Jana B, Całka J, Witek K.
europepmc   +1 more source

Viral-Mediated Knockdown of Nucleus Accumbens Shell PAC1 Receptor Promotes Excessive Alcohol Drinking in Alcohol-Preferring Rats. [PDF]

Front Behav Neurosci, 2021
Minnig MA, Park T, Echeveste Sanchez M, Cottone P, Sabino V.   +4 more
europepmc   +1 more source

PAC1 receptor-mediated clearance of tau in postsynaptic compartments attenuates tau pathology in mouse brain. [PDF]

Sci Transl Med, 2021
Schaler AW, Runyan AM, Clelland CL, Sydney EJ, Fowler SL, Figueroa HY, Shioda S, Santa-Maria I, Duff KE, Myeku N.   +9 more
europepmc   +1 more source

VPAC1 and VPAC2 receptors mediate tactile hindpaw hypersensitivity and carotid artery dilatation induced by PACAP38 in a migraine relevant mouse model

The Journal of Headache and Pain
Background Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide pivotal in migraine pathophysiology and is considered a promising new migraine drug target.
Song Guo, Rikke Holm Rasmussen, Anders Hay-Schmidt, Messoud Ashina, Ayodeji A. Asuni, Jeppe Møller Jensen, Anja Holm, Sabrina Prehn Lauritzen, Glenn Dorsam, Jens Hannibal, Birgitte Georg, David Møbjerg Kristensen, Jes Olesen, Sarah Louise Christensen   +13 more
doaj   +1 more source

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Protects Striatal Cells and Improves Motor Function in Huntington's Disease Models: Role of PAC1 Receptor. [PDF]

Front Pharmacol, 2021
Solés-Tarrés I, Cabezas-Llobet N, Lefranc B, Leprince J, Alberch J, Vaudry D, Xifró X.   +6 more
europepmc   +1 more source

ePresentation

European Journal of Neurology, Volume 32, Issue S1, June 2025.
wiley   +1 more source

PAC1 receptor blockade reduces central nociceptive activity: new approach for primary headache? [PDF]

Pain, 2020
Hoffmann J, Miller S, Martins-Oliveira M, Akerman S, Supronsinchai W, Sun H, Shi L, Wang J, Zhu D, Lehto S, Liu H, Yin R, Moyer BD, Xu C, Goadsby PJ.   +14 more
europepmc   +1 more source

Intrabladder PAC1 Receptor Antagonist, PACAP(6-38), Reduces Urinary Bladder Frequency and Pelvic Sensitivity in Mice Exposed to Repeated Variate Stress (RVS). [PDF]

J Mol Neurosci, 2021
Girard BM, Campbell SE, Beca KI, Perkins M, Hsiang H, May V, Vizzard MA.   +6 more
europepmc   +1 more source

A phase 2, randomized, double-blind, placebo-controlled trial of AMG 301, a pituitary adenylate cyclase-activating polypeptide PAC1 receptor monoclonal antibody for migraine prevention. [PDF]

Cephalalgia, 2021
Ashina M, Doležil D, Bonner JH, Zhou L, Klatt J, Picard H, Mikol DD.   +6 more
europepmc   +1 more source