Results 121 to 130 of about 3,032 (163)

Prokineticin 2 neurons form diverse subpopulations in the suprachiasmatic nucleus and rely on VPAC2-signaling for diurnal rhythmicity. [PDF]

Front Physiol
Stangerup I, Georg B, Hannibal J.
europepmc   +1 more source

Exploring the Link Between PACAP Signalling and Hyaluronic Acid Production in Melanoma Progression. [PDF]

Int J Mol Sci
Hajdú T, Kovács P, Katona É, Nguyen MN, Vágó J, Fillér C, Zákány R, Emri G, Tóth G, Reglődi D, Juhász T.   +10 more
europepmc   +1 more source

More Than Three Decades After Discovery of the Neuroprotective Effect of PACAP, What Is Still Preventing Its Clinical Use? [PDF]

J Mol Neurosci
Cherait A, Xifró X, Reglodi D, Vaudry D.   +3 more
europepmc   +1 more source

eLife assessment: Probing PAC1 receptor activation across species with an engineered sensor

openaire   +1 more source

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PAC1 Receptor

Annals of the New York Academy of Sciences, 2006
Abstract: Septic shock is a systemic response to severe bacterial infections, generally caused by Gram‐negative bacterial endotoxins, with multiple manifestations such as hypotension, tissue injury, disseminated intravascular coagulation, and multi‐organ failure.
Carmen, Martínez, Alicia, Arranz, Yasmina, Juarranz, Catalina, Abad, María, García-Gómez, Florencia, Rosignoli, Javier, Leceta, Rosa P, Gomariz   +7 more
openaire   +2 more sources

Maxadilan, the PAC1 Receptor, and Leishmaniasis

Journal of Molecular Neuroscience, 2008
Maxadilan is a vasodilator peptide isolated from sand fly salivary glands. The vasodilator effects of maxadilan are mediated by the PAC1 receptor, although maxadilan and PACAP do not share sequence homology. Sand flies are the vector of the parasitic disease leishmaniasis.
Vemuri B, Reddy, Yhong, Li, Ethan A, Lerner   +2 more
openaire   +2 more sources

Maxadilan Activates PAC1 Receptors Expressed in Xenopus laevis Melanophores

Pigment Cell Research, 2002
Functional interactions between ligands and their cognate receptors can be investigated using the ability of melanophores from Xenopus laevis to disperse or aggregate their pigment granules in response to alterations in the intracellular levels of second messengers.
Phyllis, Pereira, Vermuri B, Reddy, Kounga, Kounga, Ysabel, Bello, Ethan, Lerner   +4 more
openaire   +2 more sources

Expression of PAC1 receptor in rat thymus after irradiation

Regulatory Peptides, 2004
In the present work, PAC1-R (G-protein-coupled receptor specific for PACAP) was detected on cells in the normal thymus. Immunohistochemically PAC1-R was expressed strongly in stromal cells of the thymic medulla. Positive cells were also observed in the thymus of fetal and old adult rats.
Nobuko, Tokuda, Keiko, Hamasaki, Noriko, Mizutani, Yasuhiro, Adachi, Tomoo, Sawada, Hisayuki, Funahashi, Seiji, Shioda, Tetsuo, Fukumoto   +7 more
openaire   +2 more sources

PACAP and PAC1 receptor in brain development and behavior

Neuropeptides, 2013
Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) act through three class B G-protein coupled receptors, PAC1, VPAC1 and VPAC2, initiating multiple signaling pathways. In addition to natural peptides ligands, a number of synthetic peptides and a small molecular antagonist have been generated. Genetically
Sanbing, Shen, Donald R, Gehlert, David A, Collier   +2 more
openaire   +2 more sources

The G Protein–Coupled Receptor PAC1 Regulates Transactivation of the Receptor Tyrosine Kinase HER3

Journal of Molecular Neuroscience, 2020
Peptide G protein-coupled receptors (GPCRs) for pituitary adenylate cyclase activating polypeptide (PACAP) regulate the growth of non-small cell lung cancer (NSCLC) cells. PACAP binds with high affinity to PAC1, which causes transactivation of receptor tyrosine kinases (RTK) for the EGFR and HER2 but its effect on HER3 is unknown.
Terry W. Moody, Lingaku Lee, Robert T. Jensen   +2 more
openaire   +2 more sources