Results 131 to 140 of about 3,032 (163)

Characterization of four receptor cDNAs: PAC1, VPAC1, a novel PAC1 and a partial GHRH in zebrafish

Molecular and Cellular Endocrinology, 2005
To understand the role of growth hormone-releasing hormone (GHRH) and pituitary adenylate cyclase-activating polypeptide (PACAP) and to examine the functional significance of the co-expression of GHRH and PACAP in fish, their receptors were characterized in zebrafish.
Erica A, Fradinger, Javier A, Tello, Jean E, Rivier, Nancy M, Sherwood   +3 more
openaire   +2 more sources

Novel stable PACAP analogs with potent activity towards the PAC1 receptor

Peptides, 2008
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 38- or 27-amino acid neuropeptide with promising therapeutic applications for the treatment of several pathophysiological states related to neurodegenerative diseases. However, its use for therapeutic applications is actually limited by its restricted bioavailability and rapid degradation.
Steve, Bourgault, David, Vaudry, Béatrice, Botia, Alain, Couvineau, Marc, Laburthe, Hubert, Vaudry, Alain, Fournier   +6 more
openaire   +2 more sources

PACAP Receptor (PAC1‐R) Expression in Rat and Rhesus Monkey Thymus

Annals of the New York Academy of Sciences, 2006
Abstract: The expression of PACAP receptor (PAC1‐R) was investigated in the thymus of rats and rhesus monkeys. In the rat thymus, PAC1‐R positive cells were found in the intermediate type of thymic epithelial cells of the medulla. PAC1‐R‐positive cells were also seen in the thymic medulla of the rhesus monkey.
N, Tokuda, Y, Arudchelvan, T, Sawada, Y, Adachi, T, Fukumoto, M, Yasuda, H, Sumida, S, Shioda, T, Fukuda, A, Arima, S, Kubota   +10 more
openaire   +2 more sources

The functional recombinant first extracellular (EC1) domain of PACAP receptor PAC1 normal form (PAC1-EC1(N)) recognizes selective ligands and stimulates the proliferation of PAC1-CHO cells

Neuroscience Letters, 2010
PAC1 is a pituitary adenylate cyclase-activating polypeptide (PACAP) preferring receptor, which is abundant in the central and peripheral nervous systems. PAC1 belongs to the class B family of G protein-coupled receptors (GPCRs). The N-terminal first extracellular (EC1) domain of PAC1 is responsible for ligand recognition and binding.
Rongjie, Yu, Juan, Li, Jingjing, Wang, Xiaofei, Liu, Lin, Huang, Yong, Ding, Jiansu, Chen   +6 more
openaire   +2 more sources

Markedly reduced chronic nociceptive response in mice lacking the PAC1 receptor

Neuroreport, 2001
The neuropeptide pituitary adenylate cyclase activating polypeptide (PACAP) has been proposed to have a role in nociception. Here we have used the formalin test, thermal laser stimulation and mechanical von Frey stimulation to investigate possible alteration of PAC1-/- mice nociceptive behaviour.
H, Jongsma, L M, Pettersson, , Zhang Yz, M K, Reimer, M, Kanje, A, Waldenström, F, Sundler, N, Danielsen   +7 more
openaire   +2 more sources

Strategy for the development of small-molecule antidepressant targeting PAC1 receptor

Folia Pharmacologica Japonica
Major depressive disorder (MDD) is a psychiatric disorder that affects more than 300 million people worldwide and has a serious impact on society. Conventional antidepressants targeting monoamines in the brain based on the monoamine hypothesis are known to take a prolonged time to be effective or less effective in 30% of MDD patients. Hence, there is a
Ichiro, Takasaki, Atsuko, Hayata-Takano, Yusuke, Shintani, Takashi, Kurihara, Hitoshi, Hashimoto   +4 more
openaire   +2 more sources

The Protective Role of PAC1-Receptor Agonist Maxadilan in BCCAO-Induced Retinal Degeneration

Journal of Molecular Neuroscience, 2016
A number of studies have proven that pituitary adenylate cyclase activating polypeptide (PACAP) is protective in neurodegenerative diseases. Permanent bilateral common carotid artery occlusion (BCCAO) causes severe degeneration in the rat retina. In our previous studies, protective effects were observed with PACAP1-38, PACAP1-27, and VIP but not with ...
Váczy, Alexandra, Reglődi, Dóra, Somoskeoy, T., Kovács, Krisztina, Lőkös, Emese, Szabó, Edina, Tamás, Andrea, Atlasz, Tamás   +7 more
openaire   +3 more sources

Development of Selective Ligands for Pac1, Vpac1 and Vpac2 Receptors

2003
At the time of its isolation, purification and sequencing in 1970-1972 by Said and Mutt (Said and Mutt, 1972;Mutt and Said, 1974), VIP was the third identified member of a peptide group that included secretin (Mutt et al, 1970) and glucagon (Bromer et al, 1957).
P. Robberecht, P. Vertongen, I. Langer, J. Perret   +3 more
openaire   +1 more source

Structural motifs of pituitary adenylate cyclase-activating polypeptide (PACAP) defining PAC1-receptor selectivity

Regulatory Peptides, 1999
Pituitary adenylate cyclase-activating polypeptide (PACAP) interacts with three types of PACAP/VIP-receptors. The PAC1-receptor accepts PACAP as a high affinity ligand but not vasoactive intestinal peptide (VIP) similarly binding to VPAC1- and VPAC2-receptors. To identify those amino acids not present in VIP defining PAC1-receptor selectivity of PACAP,
H, Schäfer, J, Zheng, C, Morys-Wortmann, U R, Fölsch, W E, Schmidt   +4 more
openaire   +2 more sources

PACAP stimulates insulin secretion by PAC1 receptor and ion channels in β-cells

Cellular Signalling, 2019
Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) plays a crucial role in the endocrine system. The present study aimed to investigate the effect of PACAP38 on insulin secretion and the underlying mechanism in rat pancreatic β-cells. The insulin secretion results showed that PACAP38 stimulated insulin secretion in a glucose- and dose-dependent
Mengmeng Liu, Xiaohua Yang, Tao Bai, Zhihong Liu, Tao Liu, Yan Wang, Lijuan Cui, Yunfeng Liu, Yi Zhang   +8 more
openaire   +2 more sources