Results 11 to 20 of about 3,032 (163)

PACAP–PAC1 Signaling Regulates Serotonin 2A Receptor Internalization [PDF]

Frontiers in Endocrinology, 2021
Mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP) display psychomotor abnormalities, most of which are ameliorated by atypical antipsychotics with serotonin (5-HT) 2A receptor (5-HT2A) antagonism. Heterozygous Pacap mutant mice show
Atsuko Hayata-Takano, Atsuko Hayata-Takano, Yusuke Shintani, Keita Moriguchi, Naoki Encho, Kohei Kitagawa, Takanobu Nakazawa, Takanobu Nakazawa, Hitoshi Hashimoto, Hitoshi Hashimoto, Hitoshi Hashimoto, Hitoshi Hashimoto, Hitoshi Hashimoto   +12 more
doaj   +3 more sources

Altered Circadian Food Anticipatory Activity Rhythms in PACAP Receptor 1 (PAC1) Deficient Mice. [PDF]

PLoS ONE, 2016
Light signals from intrinsically photosensitive retinal ganglion cells (ipRGCs) entrain the circadian clock and regulate negative masking. Two neurotransmitters, glutamate and Pituitary Adenylate Cyclase Activating Polypeptide (PACAP), found in the ...
Jens Hannibal, Birgitte Georg, Jan Fahrenkrug   +2 more
doaj   +6 more sources

Distribution of PACAP and PAC1 Receptor in the Human Eye. [PDF]

J Mol Neurosci, 2022
Abstract Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide with widespread distribution and diverse biological functions. Several studies show that PACAP has strong cytoprotective effects mediated mostly through its specific PAC1 receptor (PAC1-R) and it plays important roles in several pathological conditions.
Patko E, Szabo E, Toth D, Tornoczky T, Bosnyak I, Vaczy A, Atlasz T, Reglodi D.   +7 more
europepmc   +6 more sources

PAC1 receptor modulation of freezing and flight behavior in periaqueductal gray. [PDF]

Genes Brain Behav, 2023
AbstractThe midbrain periaqueductal gray (PAG) region is a critical anatomical regulator of fear‐related species‐specific defensive reactions (SSDRs). Pituitary adenylate‐cyclase‐activating polypeptide (PACAP), and its main receptor PAC1, play an important role in fear‐related behavior and anxiety disorders.
Yavas E, Zhuravka I, Fanselow MS.
europepmc   +4 more sources

Calcitonin/PAC₁ receptor splice variants: a blind spot in migraine research. [PDF]

Trends Pharmacol Sci, 2023
The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide (PACAP) and their receptors are linked to migraine neurobiology. Recent antimigraine therapeutics targeting the signaling of these neuropeptides are effective; however, some patients respond suboptimally, indicating an incomplete ...
Rees TA, Labastida-Ramírez A, Rubio-Beltrán E.   +2 more
europepmc   +7 more sources

Probing PAC1 receptor activation across species with an engineered sensor. [PDF]

Elife
Class-B1 G-protein-coupled receptors (GPCRs) are an important family of clinically relevant drug targets that remain difficult to investigate via high-throughput screening and in animal models. Here, we engineered PAClight1 P78A , a novel genetically encoded sensor based on a class-B1 GPCR ...
Cola RB, Niethammer SN, Rajamannar P, Gresch A, Bhat MA, Assoumou K, Williams ET, Hauck P, Hartrampf N, Benke D, Stoeber M, Levkowitz G, Melzer S, Patriarchi T.   +13 more
europepmc   +6 more sources

PACAP and PAC1 receptor expression in pancreatic ductal carcinoma. [PDF]

Oncol Lett, 2019
Pancreatic carcinoma is one of the most malignant diseases and is associated with a poor survival rate. Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide that acts on three different G protein-coupled receptors: the specific PAC1 and the VPAC1/2 that also bind vasoactive intestinal peptide.
Ferencz S, Reglodi D, Kaszas B, Bardosi A, Toth D, Vekony Z, Vicena V, Karadi O, Kelemen D.   +8 more
europepmc   +4 more sources

Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism. [PDF]

Cell Res, 2020
AbstractThe pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1R) belongs to the secretin receptor family and is widely distributed in the central neural system and peripheral organs. Abnormal activation of the receptor mediates trigeminovascular activation and sensitization, which is highly related to migraine, making PAC1R a ...
Wang J, Song X, Zhang D, Chen X, Li X, Sun Y, Li C, Song Y, Ding Y, Ren R, Harrington EH, Hu LA, Zhong W, Xu C, Huang X, Wang HW, Ma Y.   +16 more
europepmc   +4 more sources

Targeting the PAC1 Receptor for Neurological and Metabolic Disorders. [PDF]

Curr Top Med Chem, 2019
The pituitary adenylate cyclase-activating polypeptide (PACAP)-selective PAC1 receptor (PAC1R, ADCYAP1R1) is a member of the vasoactive intestinal peptide (VIP)/secretin/glucagon family of G protein-coupled receptors (GPCRs). PAC1R has been shown to play crucial roles in the central and peripheral nervous systems.
Liao C, de Molliens MP, Schneebeli ST, Brewer M, Song G, Chatenet D, Braas KM, May V, Li J.   +8 more
europepmc   +5 more sources

PACAP and PAC1 Receptor Expression in Human Insulinomas [PDF]

International Journal of Peptide Research and Therapeutics, 2021
AbstractPituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide with widespread occurrence and diverse functions. PACAP binds to specific PAC1 and non-specific VPAC1/2 receptors. PACAP is considered as a growth factor, as it plays important roles during development and participates in reparative processes.
Ferencz, Sándor, Tóth, Dénes, Kaszás, Bálint, Bárdosi, Sebastian, Vicena, Viktória, Karádi, Oszkár, Reglődi, Dóra, Kelemen, Dezső   +7 more
openaire   +2 more sources