Results 31 to 40 of about 3,032 (163)

Secreted key regulators (Fgf1, Bmp4, Gdf3) are expressed by PAC1-immunopositive retinal ganglion cells in the postnatal rat retina

European Journal of Histochemistry, 2022
Identified as a member of the secretin/glucagon/VIP superfamily, pituitary adenylate cyclase-activating polypeptide (PACAP1-38) has been recognized as a hormone, neurohormone, transmitter, trophic factor, and known to be involved in diverse and multiple
Viktória Dénes, Kármen Kovacs, Ákos Lukáts, Adrienn Mester, Gergely Berta, Arnold Szabó, Robert Gabriel   +6 more
doaj   +1 more source

Pituitary Adenylate Cyclase Activating Peptide and Post-traumatic Stress Disorder: From Bench to Bedside

Frontiers in Psychiatry, 2022
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide with isoforms consisting of either 27 or 38 amino acids. PACAP is encoded by the adenylate cyclase activating peptide gene, ADCYAP1, in humans and the highly conserved ...
Manessa Riser, Seth Davin Norrholm
doaj   +1 more source

Seasonal changes in the expression of PACAP, VPAC1, VPAC2, PAC1 and testicular activity in the testis of the muskrat (Ondatra zibethicus)

European Journal of Histochemistry, 2022
Pituitary adenylate cyclase-activating polypeptide (PACAP) plays an important role in the steroidogenesis and spermatogenesis in the testis through its receptors PAC1, VPAC1, and VPAC2.
Zeqi Tang, Xiaojie Yuan, Yuming Bai, Yiming Guo, Haolin Zhang, Yingying Han, Zhengrong Yuan, Qiang Weng   +7 more
doaj   +1 more source

PACAP-38 and PACAP(6–38) Degranulate Rat Meningeal Mast Cells via the Orphan MrgB3-Receptor

Frontiers in Cellular Neuroscience, 2019
Infusion of pituitary adenylate cyclase activating peptide-38 (PACAP-38) provokes migraine attacks in migraineurs and headache in non-migraineurs. Adverse events like long-lasting flushing and heat sensation can be terminated with oral antihistamine ...
Sara Hougaard Pedersen, Sara Hougaard Pedersen, Sanne Hage la Cour, Sanne Hage la Cour, Kirstine Calloe, Frank Hauser, Jes Olesen, Jes Olesen, Dan Arne Klaerke, Inger Jansen-Olesen, Inger Jansen-Olesen   +10 more
doaj   +1 more source

Sexually dimorphic role of the locus coeruleus PAC1 receptors in regulating acute stress-associated energy metabolism

Frontiers in Behavioral Neuroscience, 2022
Severe stress leads to alterations in energy metabolism with sexually dimorphic onset or severity. The locus coeruleus (LC) in the brainstem that mediates fight-or-flight-or-freeze response to stress is sexually dimorphic in morphology, plays a key role ...
Samuel J. Duesman, Sanutha Shetty, Sanil Patel, Neha Ogale, Farzanna Mohamed, Njeri Sparman, Prashant Rajbhandari, Abha Karki Rajbhandari   +7 more
doaj   +1 more source

Protective effects of PACAP in ischemia

The Journal of Headache and Pain, 2018
Pituitary adenylate cyclase activating polypeptide (PACAP) is an ubiquitous peptide involved, among others, in neurodevelopment, neuromodulation, neuroprotection, neurogenic inflammation and nociception. Presence of PACAP and its specific receptor, PAC1,
Dora Reglodi, Alexandra Vaczy, Eloísa Rubio-Beltran, Antoinette MaassenVanDenBrink   +3 more
doaj   +1 more source

Localization of the neuropeptides pituitary adenylate cyclase-activating polypeptide, vasoactive intestinal peptide, and their receptors in the basal brain blood vessels and trigeminal ganglion of the mouse CNS; an immunohistochemical study

Frontiers in Neuroanatomy, 2022
Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are structurally related neuropeptides that are widely expressed in vertebrate tissues. The two neuropeptides are pleiotropic and have been associated with
Anne Marie Lund, Anne Marie Lund, Jens Hannibal, Jens Hannibal   +3 more
doaj   +1 more source

Pleural mesothelioma from fluoro-edenite exposure: PACAP and PAC1 receptor. A preliminary report. [PDF]

Eur J Histochem
Pleural mesothelioma is a devastating malignancy primarily associated with asbestos exposure. However, emerging evidence suggests that exposure to fluoro-edenite fibers, a naturally occurring mineral fiber, can also lead to the development of pleural mesothelioma.
Lombardo C, Maugeri G, D'Amico AG, Broggi G, Caltabiano R, Filetti V, Matera S, D'Agata V, Loreto C.   +8 more
europepmc   +4 more sources

PACAP and the PAC1 receptor in post-traumatic stress disorder. [PDF]

Neuropsychopharmacology, 2013
Post-traumatic stress disorder (PTSD) affects approximately 5–10% of all individuals and is more predominant in women (Breslau, 2001). Advances in treatment and prevention will require identifying biomarkers to aid early diagnosis and understanding the mechanisms underlying maladaptive responses to trauma.
Dias BG, Ressler KJ.
europepmc   +4 more sources

Cyclical depressurization degranulates platelets in an agonist-free mechanism of platelet activation

PLoS ONE, 2022
Activation of circulating platelets by receptor binding and subsequent coagulation events are defined by a well characterized physiological response. However, the growing prevalence of chronic kidney disease (CKD) and implication of platelet-released ...
Aaron J. Velasquez-Mao, Mark Velasquez, Moriel H. Vandsburger   +2 more
doaj   +2 more sources