Results 41 to 50 of about 3,032 (163)
Journal of Pharmacological Sciences, 2019 We recently developed PA-8, a novel small-molecule antagonist of PACAP type 1 (PAC1) receptor. In the present study, we examined whether PA-8 was effective against formalin-induced inflammatory pain in mice. Both intrathecal and oral administration of PA-
Ichiro Takasaki +8 more
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In Silico Screening Identified Novel Small-molecule Antagonists of PAC1 Receptor [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2018 Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors are present in the spinal dorsal horn and dorsal root ganglia, suggesting an important role of PACAP signaling systems in the modulation of spinal nociceptive transmission. Previously, we found that intrathecal injection of PACAP or maxadilan, a selective PACAP type I (PAC1 ...
Ichiro, Takasaki +11 more
openaire +2 more sources
Macrophage Resistance to HIV-1 Infection Is Enhanced by the Neuropeptides VIP and PACAP. [PDF]
PLoS ONE, 2013 It is well established that host factors can modulate HIV-1 replication in macrophages, critical cells in the pathogenesis of HIV-1 infection due to their ability to continuously produce virus.
Jairo R Temerozo +4 more
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PLoS ONE, 2014 The high expression of PACAP (pituitary adenylate cyclase-activating polypeptide)-preferring receptor PAC1 is associated with nerve injury and tumors. Our previous report (Yu R, et al.
Rongjie Yu +4 more
doaj +1 more source
Frontiers in Endocrinology, 2013 Alternative splicing of the precursor mRNA encoding for the neuropeptide receptor PAC1/ADCYAP1R1 generates multiple protein products that exhibit pleiotropic activities.
Janna eBlechman, Gil eLevkowitz
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β-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking. [PDF]
PLoS One, 2018 A pituitary adenylate cyclase-activating polypeptide (PACAP)-specific receptor, PAC1R, is coupled with multiple signal transduction pathways including stimulation of adenylate cyclase, phospholipase C and extracellular-signal regulated kinase (ERK)1/2.
Shintani Y +8 more
europepmc +5 more sources
Discovery of PACAP and its receptors in the brain
The Journal of Headache and Pain, 2018 Pituitary adenylate-cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide (VIP)/glucagon/secretin family. PACAP shows particularly high homology (~ 68%) to VIP.
Takahiro Hirabayashi +2 more
doaj +1 more source
Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor [PDF]
Nature, 2011 Pituitary adenylate cyclase-activating polypeptide (PACAP) is known to broadly regulate the cellular stress response. In contrast, it is unclear if the PACAP-PAC1 receptor pathway has a role in human psychological stress responses, such as post-traumatic stress disorder (PTSD).
Ressler, K. +16 more
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Maxadilan prevents apoptosis in iPS cells and shows no effects on the pluripotent state or karyotype. [PDF]
PLoS ONE, 2012 Pituitary adenylate cyclase-activating polypeptide (PACAP) is a structurally endogenous peptide with many biological roles. Maxadilan, a 61-amino acid vasodilatory peptide, specifically activates the PACAP type I receptor (PAC1).
Zhiyi Zhao +6 more
doaj +1 more source
Pituitary Adenylate Cyclase-Activating Polypeptide in Learning and Memory
Frontiers in Cellular Neuroscience, 2021 Pituitary adenylate cyclase-activating polypeptide (PACAP) is a highly conserved neuropeptide that regulates neuronal physiology and transcription through Gs/Gq-coupled receptors. Its actions within hypothalamic, limbic, and mnemonic systems underlie its
Marieke R. Gilmartin, Nicole C. Ferrara
doaj +1 more source