Results 51 to 60 of about 3,032 (163)

Pituitary adenylate cyclase activating polypeptide (PACAP) signalling exerts chondrogenesis promoting and protecting effects: implication of calcineurin as a downstream target. [PDF]

PLoS ONE, 2014
Pituitary adenylate cyclase activating polypeptide (PACAP) is an important neurotrophic factor influencing differentiation of neuronal elements and exerting protecting role during traumatic injuries or inflammatory processes of the central nervous system.
Tamás Juhász, Csaba Matta, Éva Katona, Csilla Somogyi, Roland Takács, Pál Gergely, László Csernoch, Gyorgy Panyi, Gábor Tóth, Dóra Reglődi, Andrea Tamás, Róza Zákány   +11 more
doaj   +1 more source

Improved platelet recovery in cryopreserved platelets reconstituted in freeze‐dried plasma

Transfusion, EarlyView.
Abstract Background Cryopreserved platelets can support availability in settings where fresh platelets are inaccessible. Freeze‐dried plasma (FDP) may serve as an alternative reconstitution medium to fresh frozen plasma (FFP) when plasma thawing is impractical. The effects of FDP on cryopreserved platelet quality remain underexplored. Thus, we aimed to
Kristina Ehn, Per Sandgren, Klara Asplund Högelin, Agneta Wikman   +3 more
wiley   +1 more source

Development-related alternative splicing of PAC1 receptor: a key player in schizophrenia? [PDF]

Frontiers in Molecular Neuroscience, 2013
Alternative splicing is the process by which various combinations of exons are included in a mature mRNA, thus allowing a single gene to encode multiple protein isoforms with potentially different or even antagonistic properties. Proper mRNA splicing is absolutely crucial for nervous system development and its misregulation has been demonstrated in ...
Rocha-Martins, Maurício, Njaine, Brian
openaire   +3 more sources

Presence of Systemic Amyloidosis in Mice with Partial Deficiency in Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Aging

Applied Sciences, 2021
Pituitary adenylate cyclase-activating polypeptide (PACAP), a neuropeptide with widespread expression and general cytoprotective effects, is also involved in aging.
Jason Sparks, Adel Jungling, Gabriella Kiss, Laszlo Hiripi, Daniel Pham, Andrea Tamas, Orsolya Hoffmann, Sebastian Bardosi, Attila Miseta, Dora Reglodi   +9 more
doaj   +1 more source

Communicative Justice in Later Life: A Critical Discourse Study and Bioethics‐of‐Vulnerability Analysis of Older Adults' Primary Care in Spain

Nursing Inquiry, Volume 33, Issue 2, April 2026.
ABSTRACT Older adults' experiences of primary care are shaped not only by service capacity but by the language and routines through which access and care are organised. Using a qualitative Critical Discourse Studies (CDS) approach informed by the bioethics of vulnerability, we analysed interviews and focus groups with 12 community‐dwelling older adults
Pablo Martínez‐Angulo, María José Millán‐Eslava   +1 more
wiley   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, Volume 12, Issue 1, Page 65-85, Spring 2026.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

PAC1 receptor (ADCYAP1R1) genotype is associated with dark-enhanced startle in children [PDF]

Molecular Psychiatry, 2012
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a regulator of stress response across species.1 Within limbic brain circuits, PACAP signaling coordinates normal physiological stress reactions. PACAP and corticotrophin-releasing hormone work together in the bed nucleus of the stria terminalis (BNST) to modulate anxiety-like behavior.1 We ...
T, Jovanovic, S D, Norrholm, J, Davis, K B, Mercer, L, Almli, A, Nelson, D, Cross, A, Smith, K J, Ressler, B, Bradley   +9 more
openaire   +2 more sources

The Role of Extracellular Vesicles in Transient Ischaemic Attacks and Ischaemic Stroke: A Systematic Review

Journal of Extracellular Biology, Volume 5, Issue 3, March 2026.
Both transient ischaemic attack (TIA) and ischaemic stroke lead to an increase in individual cellular‐derived populations of extracellular vesicles (EVs), including endothelial, platelet and leukocyte derived. These EVs have downstream roles in the pathophysiological events associated with TIA and stroke, including dysregulated inflammation and ...
Rebecca Marie Raven, Philip Eurig James, Keith Morris, Jessica Olivia Williams   +3 more
wiley   +1 more source

Essential Dynamics Ensemble Docking for Structure-Based GPCR Drug Discovery

Frontiers in Molecular Biosciences, 2022
The lack of biologically relevant protein structures can hinder rational design of small molecules to target G protein-coupled receptors (GPCRs). While ensemble docking using multiple models of the protein target is a promising technique for structure ...
Kyle McKay, Nicholas B. Hamilton, Jacob M. Remington, Severin T. Schneebeli, Jianing Li   +4 more
doaj   +1 more source

Neurons in a Dish: A Review of In Vitro Cell Models for Studying Neurogenesis

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
Different in vitro cell models are valuable to study the different steps of neurogenesis, from the proliferation of neural stem and progenitor cells to the maturation of neurons. Pluripotent stem cells (including embryonic stem cells and induced pluripotent stem cells), immortalized human neuroblastoma cell lines (SH‐SY5Y, IMR‐32), and primary brain ...
Mariana Vassal, Ana C. Cruz, Sandra Rebelo, Filipa Martins   +3 more
wiley   +1 more source