Results 61 to 70 of about 3,032 (163)
Pituitary Adenylate Cyclase–Activating Polypeptide Stimulates Renin Secretion via Activation of PAC1 Receptors [PDF]
Journal of the American Society of Nephrology, 2007 Besides of its functional role in the nervous system, the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) is involved in the regulation of cardiovascular function. Therefore, PACAP is a potent vasodilator in several vascular beds, including the renal vasculature.
Hautmann, Matthias +8 more
openaire +3 more sources
Probing the VIPR2 Microduplication Linkage to Schizophrenia in Animal and Cellular Models
Frontiers in Neuroscience, 2021 Pituitary adenylate cyclase-activating polypeptide (PACAP, gene name ADCYAP1) is a multifunctional neuropeptide involved in brain development and synaptic plasticity.
Yukio Ago +6 more
doaj +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors
British Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +206 more
wiley +1 more source
Impaired neonatal cardiorespiratory responses to hypoxia in mice lacking PAC1 or VPAC2 receptors [PDF]
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2019 The stress peptide pituitary adenylate cyclase activating polypeptide (PACAP) and its specific receptor PACAP type 1 receptor (PAC1) have been implicated in sudden infant death syndrome (SIDS). PACAP is also critical to the neonatal cardiorespiratory response to homeostatic stressors identified in SIDS, including hypoxia.
Karlene T. Barrett +3 more
openaire +2 more sources
Neurobiology of Disease, 2017 Pituitary adenylate cyclase activating polypeptide (PACAP) and its complementary receptor, PAC1, are crucial in central respiratory control. PACAP Knockout (KO) mice exhibit a SIDS-like phenotype, with an inability to overcome noxious insults ...
J. Huang, K.A. Waters, R. Machaalani
doaj +1 more source
Synapse, Volume 79, Issue 6, November 2025.ABSTRACT Low‐dose ketamine is an efficacious antidepressant for treatment‐resistant unipolar and bipolar depressed patients. Major depressive disorder patients receiving a single infusion report elevated mood within 2 h, and ketamine's antidepressant effects have been observed as long as 7 days posttreatment.
Oliver H. Miller +5 more
wiley +1 more source
Journal of Pharmacological Sciences, 2016 Intrathecal (i.t.) administration of pituitary adenylate cyclase-activating polypeptide (PACAP) induces long-lasting nociceptive behaviors for more than 60 min in mice, while the involvement of PACAP type1 receptor (PAC1-R) has not been clarified yet ...
Tetsuya Ohnou +8 more
doaj +1 more source
PACAP interacts with PAC1 receptors to induce tissue plasminogen activator (tPA) expression and activity in schwann cell-like cultures. [PDF]
PLoS ONE, 2015 Regeneration of peripheral nerves depends on the abilities of rejuvenating axons to migrate at the injury site through cellular debris and altered extracellular matrix, and then grow along the residual distal nerve sheath conduit and reinnervate synaptic
Alessandro Castorina +4 more
doaj +1 more source
Impact of N‐linked glycans on the dual short fibulin/LTBP‐4 axes regulating elastogenesis
The FEBS Journal, Volume 292, Issue 21, Page 5676-5696, November 2025.Elastic fiber assembly is orchestrated by multiple glycoproteins. We delineate the molecular basis of two key axes involved in elastic fiber formation—LTBP‐4L/fibulin‐4 and LTBP‐4S/fibulin‐5. We show that N‐linked glycans on these glycoproteins regulate their interactions and conformations, both of which are critical aspects in elastic fiber formation.
Valentin Nelea +8 more
wiley +1 more source
Signal Transduction by VIP and PACAP Receptors
Biomedicines, 2022 Homeostasis of the human immune system is regulated by many cellular components, including two neuropeptides, VIP and PACAP, primary stimuli for three class B G protein-coupled receptors, VPAC1, VPAC2, and PAC1.
Ingrid Langer +4 more
doaj +1 more source