Results 81 to 90 of about 3,032 (163)
PACAP38 in human models of primary headaches
The Journal of Headache and Pain, 2017 Background To review the role of PACAP38 in human models of primary headaches, discuss possible mechanisms of PACAP38-induced migraine, and outline future directions.
Håkan Ashina +3 more
doaj +1 more source
Skin microbiome engineering: Challenges and opportunities in skin diseases treatment
iMetaOmics, Volume 2, Issue 2, June 2025.The skin microbiome plays a crucial role in skin health, influencing barrier integrity, immune responses, and disease susceptibility. Various interventions can reshape the microbiome, broadly categorized into targeted and untargeted approaches. Targeted strategies, such as phage therapy, engineered bacteria, and phage lysins, selectively modulate ...
Yiang Lyu, Juntao Shen, You Che, Lei Dai
wiley +1 more source
mGluR5 in Pyramidal Neurons in the Hippocampus Mediates Chronic Stress‐Induced Memory Deficits
CNS Neuroscience &Therapeutics, Volume 31, Issue 6, June 2025.Diagrammatic representation of the role of mGluR5 in controlling memory impairments brought on by chronic stress. Chronic stress caused memory impairment, decreased GABAergic synaptic inputs, and decreased mGluR5 and PACAP levels in the hippocampus CA1.
Hong‐Cheng Lu +5 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2020 Pituitary adenylate cyclase-activating polypeptide (PACAP, ADCYAP1) dysregulation has been associated with multiple stress-related psychopathologies that may be related to altered hippocampal function.
Gregory C. Johnson +3 more
doaj +1 more source
Frontiers in Systems Neuroscience, 2017 Complex organization of CNS and PNS pathways is necessary for the coordinated and reciprocal functions of the urinary bladder, urethra and urethral sphincters.
Beatrice M. Girard +2 more
doaj +1 more source
Peptides, 2019 Pituitary adenylate cyclase activating polypeptide (PACAP) is a growth factor for lung cancer cells. PACAP-27 or PACAP-38 binds with high affinity to non-small cell lung cancer (NSCLC) cells, causing elevated cytosolic Ca2+, increased proliferation and increased phosphorylation of extracellular regulated kinase (ERK) and the epidermal growth factor ...
Terry W, Moody +7 more
openaire +3 more sources
Downregulation of PACAP and the PAC1 Receptor in the Basal Ganglia, Substantia Nigra and Centrally Projecting Edinger-Westphal Nucleus in the Rotenone model of Parkinson's Disease. [PDF]
Int J Mol Sci, 2023 Fehér M +14 more
europepmc +1 more source
Preclinical evaluation of PAC1 targeting with radiolabeled Maxadilan
Scientific Reports, 2017 There is an ongoing search for new tracers to optimize imaging of beta cell-derived tumors (insulinomas). The PAC1 receptor, expressed by insulinomas, can be used for targeting of these tumors.
Lieke Joosten +5 more
doaj +1 more source
PACAP-38 and PAC1 Receptor Alterations in Plasma and Cardiac Tissue Samples of Heart Failure Patients. [PDF]
Int J Mol Sci, 2022 Szabó D +12 more
europepmc +1 more source
Urotensin II-induced signaling involved in proliferation of vascular smooth muscle cells
Vascular Health and Risk Management, 2010 Myriam Iglewski, Stephen R GrantDepartment of Integrative Physiology, University of North Texas Health Science Center, Fort Worth, Texas, USAAbstract: The urotensin II receptor, bound by the ligand urotensin II, generates second ­messengers, ie ...
Myriam Iglewski, Stephen R Grant
doaj