Results 111 to 120 of about 2,251,963 (386)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Posttraumatic psychopathology and the pace of the epigenetic clock: a longitudinal investigation

Psychological Medicine, 2018
Background Posttraumatic stress disorder (PTSD) and stress/trauma exposure are cross-sectionally associated with advanced DNA methylation age relative to chronological age.
E. Wolf, M. Logue, Filomene G. Morrison, Elizabeth S. Wilcox, Annjanette Stone, S. Schichman, R. McGlinchey, W. Milberg, Mark W. Miller   +8 more
semanticscholar   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Urbanization Is Associated with Divergence in Pace-of-Life in Great Tits

Frontiers in Ecology and Evolution, 2017
As an extension of the classic life history theory, the recently highlighted pace-of-life syndrome hypothesis predicts the coevolution of behavioural, physiological and life-history traits. For instance, bolder and shyer individuals do not only differ in
A. Charmantier, Virginie Demeyrier, M. Lambrechts, Samuel Perret, A. Grégoire   +4 more
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Turismo di guerra, turismo di pace: sguardi incrociati su Italia e Francia

Diacronie. Studi di Storia Contemporanea, 2013
This contribution deals with the link between tourism and the opposite concepts of war and peace during the two World Wars, comparing the Italian framework and the French one.
Elisa Tizzoni ha conseguito il Dottorato di ricerca in Storia Contemporanea presso l’Università di Pisa ed è attualmente cultore della materia presso l’Università di Firenze; i suoi interessi di ricerca riguardano principalmente i tourism studies, analizzati da un punto di vista istituzionale e culturale, le questioni relative al rapporto città-campagna e le dinamiche del processo di integrazione europea.
doaj  

Participation in a Year-Long CURE Embedded into Major Core Genetics and Cellular and Molecular Biology Laboratory Courses Results in Gains in Foundational Biological Concepts and Experimental Design Skills by Novice Undergraduate Researchers

Journal of Microbiology & Biology Education, 2017
This two-year study describes the assessment of student learning gains arising from participation in a year-long curriculum consisting of a classroom undergraduate research experience (CURE) embedded into second-year, major core Genetics and Cellular and
Marcy A. Peteroy-Kelly, Matthew R. Marcello, Erika Crispo, Zafir Buraei, Daniel Strahs, Marisa Isaacson, Leslie Jaworski, David Lopatto, David Zuzga   +8 more
doaj   +1 more source

Normalization of bundle branch block patterns by distal His bundle pacing. Clinical and experimental evidence of longitudinal dissociation in the pathologic his bundle. [PDF]

, 1978
N El-Sherif, F Amay-Y-Leon, C Schonfield, B. J. Scherlag, Kenneth Rosen, Ralph Lazzara, Christopher R.C. Wyndham   +6 more
openalex   +1 more source

ELAN development, keeping pace with communities' needs [PDF]

, 2012
ELAN is a versatile multimedia annotation tool that is being developed at the Max Planck Institute for Psycholinguistics. About a decade ago it emerged out of a number of corpus tools and utilities and it has been extended ever since.
Sloetjes, H., Somasundaram, A.
core   +1 more source

Impact of early personal‐history characteristics on the Pace of Aging: implications for clinical trials of therapies to slow aging and extend healthspan

Aging Cell, 2017
Therapies to extend healthspan are poised to move from laboratory animal models to human clinical trials. Translation from mouse to human will entail challenges, among them the multifactorial heterogeneity of human aging.
Daniel W Belsky, A. Caspi, H. Cohen, W. Kraus, S. Ramrakha, R. Poulton, T. Moffitt   +6 more
semanticscholar   +1 more source