Results 121 to 130 of about 619,205 (369)

Urbanization Is Associated with Divergence in Pace-of-Life in Great Tits

open access: yesFrontiers in Ecology and Evolution, 2017
As an extension of the classic life history theory, the recently highlighted pace-of-life syndrome hypothesis predicts the coevolution of behavioural, physiological and life-history traits. For instance, bolder and shyer individuals do not only differ in
A. Charmantier   +4 more
semanticscholar   +1 more source

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

open access: yesMolecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi   +6 more
wiley   +1 more source

Walking Pace and the Risk of Cognitive Decline and Dementia in Elderly Populations: A Meta-analysis of Prospective Cohort Studies

open access: yesThe journals of gerontology. Series A, Biological sciences and medical sciences, 2017
Background: Data on the longitudinal association of walking pace with the risk of cognitive decline and dementia are inconsistent and inconclusive. Therefore, researchers conducted a meta-analysis of prospective cohort studies to quantitatively assess ...
Minghui Quan   +7 more
semanticscholar   +1 more source

KRAS and GNAS mutations in cell‐free DNA and in circulating epithelial cells in patients with intraductal papillary mucinous neoplasms—an observational pilot study

open access: yesMolecular Oncology, EarlyView.
This study demonstrates that KRAS and GNAS mutations are more prevalent in patients with resected intraductal papillary mucinous neoplasms (IPMN) compared to those under clinical surveillance. GNAS mutations significantly differ between the two patient cohorts, indicating that their absence may serve as a potential biomarker to support conservative ...
Christine Nitschke   +12 more
wiley   +1 more source

Enhancing Nearest Neighbor Classification Performance through Dynamic Time Warping with Progressive Constraint

open access: yesProceedings of the International Florida Artificial Intelligence Research Society Conference
Dynamic time warping (DTW) is a widely used metric for comparing time series data, offering elasticity in alignment. While the original DTW allows infinite elasticity without penalty, the wDTW imposes a constant penalty regardless of elastic length.
Sung-Hyuk Cha, Teryn Cha, Teja Vuppu
doaj   +1 more source

Impact of early personal‐history characteristics on the Pace of Aging: implications for clinical trials of therapies to slow aging and extend healthspan

open access: yesAging Cell, 2017
Therapies to extend healthspan are poised to move from laboratory animal models to human clinical trials. Translation from mouse to human will entail challenges, among them the multifactorial heterogeneity of human aging.
Daniel W Belsky   +6 more
semanticscholar   +1 more source

On‐treatment dynamics of circulating extracellular vesicles in the first‐line setting of patients with advanced non‐small cell lung cancer: the LEXOVE prospective study

open access: yesMolecular Oncology, EarlyView.
The LEXOVE prospective study evaluated plasma cell‐free extracellular vesicle (cfEV) dynamics using Bradford assay and dynamic light scattering in metastatic non‐small cell lung cancer patients undergoing first‐line treatments, correlating a ∆cfEV < 20% with improved median progression‐free survival in responders versus non‐responders.
Valerio Gristina   +17 more
wiley   +1 more source

Steric and Stereochemical Modulation in Pyridyl- and Quinolyl-Containing Ligands

open access: yesMolecules, 2016
Nitrogen-containing pyridine and quinoline are outstanding platforms on which excellent ionophores and sensors for metal ions can be built. Steric and stereochemical effects can be used to modulate the affinity and selectivity of such ligands toward ...
Zhaohua Dai
doaj   +1 more source

A Practical Guide to Budget Pacing Algorithms in Digital Advertising [PDF]

open access: yesarXiv
A typical real-time ad-serving funnel comprises ad targeting, conversion modeling (e.g., click-through rate prediction), budget pacing (bidding), and auction processes. While there is a wealth of research and articles on ad targeting and conversion modeling, budget pacing,a crucial component,lacks a systematic treatment specifically tailored for ...
arxiv  

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