Results 141 to 150 of about 619,205 (369)

The PTTG1/VASP axis promotes oral squamous cell carcinoma metastasis by modulating focal adhesion and actin filaments

Molecular Oncology, EarlyView.
VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park, Sang Shin Lee, Shihyun Kim, Yeonjun Lee, Gyeonwon Park, Jung Oh Kim, Jongho Choi   +6 more
wiley   +1 more source

Garmin Fénix 7® Underestimates Performance at the Lactate Threshold in Comparison to Standardized Blood Lactate Field Test

Open Access Journal of Sports Medicine
Marie Heiber,1,* Andrea Schittenhelm,1,* Jennifer Schlie,2,* Marcus Beckert,2 Pascal Graf,2 Annette Schmidt1– 3 1dtec.bw, NextGenerationEU Project Smart Health Lab, University of the Bundeswehr, Chair of Sport Biology Munich, Munich, Germany;
Heiber M, Schittenhelm A, Schlie J, Beckert M, Graf P, Schmidt A   +5 more
doaj  

Constant Inapproximability of Pacing Equilibria in Second-Price Auctions [PDF]

arXiv
In this paper, we revisit the problem of approximating a pacing equilibrium in second-price auctions, introduced by Conitzer, Kroer, Sodomka, and Moses [Oper. Res. 2022]. We show that finding a constant-factor approximation of a pacing equilibrium is PPAD-hard, thereby strengthening previous results of Chen, Kroer, and Kumar [Math. Oper. Res.
arxiv  

NanoCMSer: a consensus molecular subtype stratification tool for fresh‐frozen and paraffin‐embedded colorectal cancer samples

Molecular Oncology, EarlyView.
Consensus molecular subtypes (CMS1‐4) have been identified to study colorectal cancer heterogeneity and serve as potential biomarkers. In this study, we developed and evaluated NanoCMSer, a NanoString‐based classifier using 55 genes, optimized for FF and FFPE to facilitate the clinical evaluation of CMS subtyping.
Arezo Torang, Simone van de Weerd, Veerle Lammers, Sander van Hooff, Inge van den Berg, Saskia van den Bergh, Miriam Koopman, Jan N. IJzermans, Jeanine M. L. Roodhart, Jan Koster, Jan Paul Medema   +10 more
wiley   +1 more source

Enhancing Image Classification through Exploitation of Hue Cyclicity in Convolutional Neural Networks

Proceedings of the International Florida Artificial Intelligence Research Society Conference
This study introduces innovative methodologies for image classification employing Convolutional Neural Networks (CNNs) by leveraging the cyclical attributes of hue within the HSV color space.
Jiatao Kuang, Teryn Cha, Sung-Hyuk Cha
doaj   +1 more source

Terminating ventricular tachycardia by pacing induced dynamical inhomogeneities in the reentry circuit [PDF]

arXiv, 2004
Formation of feedback loops of excitation waves (reentrant circuit) around non-conducting ventricular scar tissue is a common cause of lethal cardiac arrhythmias, such as ventricular tachycardia. This is typically treated by rapid stimulation from an implantable device (ICD). However, the mechanisms of reentry termination success and, more importantly,
arxiv  

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Protocol: What works to increase the use of evidence for policy decision‐making: A systematic review

Campbell Systematic Reviews
This is the protocol for a Campbell systematic review. The objectives are as follows: Our aim is to collect, assess, and synthesise all the available empirical evidence on what works to support evidence‐informed decision‐making by policymakers.
Promise Nduku, John Ategeka, Andile Madonsela, Tanya Mdlalose, Jennifer Stevenson, Shannon Shisler, Suvarna Pande, Laurenz Mahlanza‐Langer   +7 more
doaj   +1 more source

The Primal Scream: Re-Reading the “Temporality” Chapter of Phenomenology of Perception in the Context of Negative Philosophy

Philosophies
Merleau-Ponty’s specific theory of negation has received surprisingly little attention within the literature. Given his engagement with Sartre, not to mention Hegel and Marx, one would think that this concept and its surrounding issues and problems would
Keith Whitmoyer
doaj   +1 more source

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

Molecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran, Clarence Yapp, Gregory J. Baker, Johanna Beyer, Young Hwan Chang, Allison L. Creason, Robert Krueger, Jeremy Muhlich, Nathan Heath Patterson, Kevin Sidak, Damir Sudar, Adam J. Taylor, Luke Ternes, Jakob Troidl, Xie Yubin, Artem Sokolov, Darren R. Tyson   +16 more
wiley   +1 more source