Results 211 to 220 of about 2,050,605 (416)

Clinical significance of stratifying prostate cancer patients through specific circulating genes

open access: yesMolecular Oncology, EarlyView.
We tested a specific panel of genes representative of luminal, neuroendocrine and stem‐like cells in the blood of prostate cancer patients, showing predictive value from diagnosis to late stages of disease. This approach allows monitoring of treatment responses and outcomes at specific time points in trajectories.
Seta Derderian   +12 more
wiley   +1 more source

An Analysis of Pacing Profiles in Sprint Kayak Racing Using Functional Principal Components and Hidden Markov Models [PDF]

open access: yesarXiv
This study analysed sprint kayak pacing profiles in order to categorise and compare an athlete's race profile throughout their career. We used functional principal component analysis of normalised velocity data for 500m and 1000m races to quantify pacing.
arxiv  

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

Online Fair Allocation with Best-of-Many-Worlds Guarantees [PDF]

open access: yesarXiv
We investigate the online fair allocation problem with sequentially arriving items under various input models, with the goal of balancing fairness and efficiency. We propose the unconstrained PACE (Pacing According to Current Estimated utility) algorithm, a parameter-free allocation dynamic that requires no prior knowledge of the input while using only
arxiv  

StorySpinner: Controlling Narrative Pace in Hyperfiction

open access: yes, 2005
This paper describes the StorySpinner system, a sculptural hypertext reader used as a test bed for experimenting with the authoring of narrative flow in automatically generated stories.
Hooper, Clare, Weal, Mark J.
core  

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

open access: yesMolecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita   +1 more
wiley   +1 more source

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