Results 271 to 280 of about 2,251,963 (386)

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Determining Good Candidates for Atrioventricular Junction Ablation and Device Therapy and Which Device to Implant. [PDF]

Arrhythm Electrophysiol Rev
Bisson A, Lenormand T, Jacobs M, Fauchier L.   +3 more
europepmc   +1 more source

The Influence of Course Bends on Pacing Strategy in Road Cycling

, 2014
David Sundström, Peter Carlsson, Mats Tinnsten   +2 more
openalex   +1 more source

Saturday Morning Parent and Child Education (PACE) [PDF]

, 2001
Bagby, D. J., Priestas, P. A.
core   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Handgrip strength and walking pace negatively impact the incidents of diabetes mellitus among people with HIV: a prospective cohort study in China. [PDF]

BMJ Open
Meng Q, Guo C, Xie Y, Zhang H, Chen X, Wang S, Hua T, Wang Y, Wang T, Lin H, He N.   +10 more
europepmc   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Effective transition from standing to groundwork combat: an analysis of judo athletes with visual impairments. [PDF]

Front Sports Act Living
Detanico D, Gulias VOS, Gomes NAB, Kons RL.   +3 more
europepmc   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Causal relationship between sarcopenia and cognitive performance: A bidirectional Mendelian randomization study. [PDF]

Medicine (Baltimore)
Zhou Y, Guo X, Dong S, Wang C, Wu L, Liu W.   +5 more
europepmc   +1 more source