Results 41 to 50 of about 619,205 (369)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
A Survey of Binary Similarity and Distance Measures [PDF]
Journal of Systemics, Cybernetics and Informatics, 2010 The binary feature vector is one of the most common representations of patterns and measuring similarity and distance measures play a critical role in many problems such as clustering, classification, etc. Ever since Jaccard proposed a similarity measure
Seung-Seok Choi +2 more
doaj
Metabolic rate evolves rapidly and in parallel with the pace of life history
Nature Communications, 2018 Metabolic rates and life history strategies are both thought to set the “pace of life”, but whether they evolve in tandem is not well understood. Here, using a common garden experiment that compares replicate paired populations, we show that Trinidadian ...
S. Auer +3 more
semanticscholar +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Diphthamide synthesis is linked to the eEF2‐client chaperone machinery
FEBS Letters, EarlyView.The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr +4 more
wiley +1 more source
Analysis of ice climber sport performance during competition [PDF]
Fizička Kultura, 2018 Sport discipline ice climbing was built on the reputation of climbing frozen waterfalls and can be defined as a unique discipline under the International Climbing and Mountaineering Federation (UIAA) in artificial, prescribed conditions, and according to
Manovski Katarina +5 more
doaj
The Complexity of Pacing for Second-Price Auctions [PDF]
arXiv, 2021 Budget constraints are ubiquitous in online advertisement auctions. To manage these constraints and smooth out the expenditure across auctions, the bidders (or the platform on behalf of them) often employ pacing: each bidder is assigned a pacing multiplier between zero and one, and her bid on each item is multiplicatively scaled down by the pacing ...
arxiv
European Heart Journal, 2015 Arrhythmias remain a frequent cause of morbidity and mortality in cardiovascular (CV) patients, and thus an important issue for practising cardiologists. Therefore, the European Society of Cardiology has published guidelines on cardiac pacing and resynchronization therapy1 and on atrial fibrillation,2 syncope,3 and ventricular arrhythmias,4 and ...
openaire +4 more sources
Pacing technology: advances in pacing threshold management [PDF]
Journal of Zhejiang University SCIENCE B, 2010 Over the last five decades, pacemaker therapy has undergone remarkable technological advances with increasing sophistication of pacemaker features. However, device longevity has remained one of the major issues in pacemaker design ever since the first endocardial pacing lead implantation in 1958. In addition to various hardware design to enhance device
Siu, CW, Lau, CP
openaire +5 more sources
Innovation ecosystems and the pace of substitution: Re‐examining technology S‐curves
, 2016 Why do some new technologies emerge and quickly supplant incumbent technologies while others take years or decades to take off? We explore this question by presenting a framework that considers both the focal competing technologies as well as the ...
Ron Adner, R. Kapoor
semanticscholar +1 more source