Results 61 to 70 of about 619,205 (369)

The Pace of Shifting Climate in Marine and Terrestrial Ecosystems

Science, 2011
Ecologically relevant measures of contemporary global climate change can predict species distributions and vulnerabilities. Climate change challenges organisms to adapt or move to track changes in environments in space and time.
M. Burrows, D. Schoeman, Lauren B. Buckley, P. Moore, E. Poloczanska, K. Brander, Chris G. Brown, J. Bruno, Carlos M. Duarte, B. Halpern, J. Holding, Carrie V. Kappel, W. Kiessling, M. O’Connor, J. Pandolfi, C. Parmesan, F. Schwing, W. Sydeman, A. Richardson   +18 more
semanticscholar   +1 more source

Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions

FEBS Letters, EarlyView.
This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten, Lorenz Schwaiger, Zarah Forsberg, Kelsi R. Hall, Anton A. Stepnov, Tom Z. Emrich‐Mills, Iván Ayuso‐Fernández, Morten Sørlie, Roland Ludwig, Åsmund Kjendseth Røhr, Vincent G. H. Eijsink   +10 more
wiley   +1 more source

Inactivation influences the extent of inhibition of voltage-gated Ca+2 channels by Gem—implications for channelopathies

Frontiers in Physiology, 2023
Voltage-gated Ca2+ channels (VGCC) directly control muscle contraction and neurotransmitter release, and slower processes such as cell differentiation, migration, and death. They are potently inhibited by RGK GTP-ases (Rem, Rem2, Rad, and Gem/Kir), which
Salma Allam, Rose Levenson-Palmer, Zuleen Chia Chang, Sukhjinder Kaur, Bryan Cernuda, Ananya Raman, Audrey Booth, Scott Dobbins, Gabrielle Suppa, Jian Yang, Zafir Buraei   +10 more
doaj   +1 more source

PACE: Improving Prompt with Actor-Critic Editing for Large Language Model [PDF]

arXiv, 2023
Large language models (LLMs) have showcased remarkable potential across various tasks by conditioning on prompts. However, the quality of different human-written prompts leads to substantial discrepancies in LLMs' performance, and improving prompts usually necessitates considerable human effort and expertise.
arxiv  

Association of walking pace and handgrip strength with all-cause, cardiovascular, and cancer mortality: a UK Biobank observational study

European Heart Journal, 2017
Aims To quantify the association of self-reported walking pace and handgrip strength with all-cause, cardiovascular, and cancer mortality. Methods and results A total of 230 670 women and 190 057 men free from prevalent cancer and cardiovascular disease ...
T. Yates, F. Zaccardi, N. Dhalwani, M. Davies, Kishan Bakrania, C. Celis-Morales, J. Gill, P. Franks, K. Khunti   +8 more
semanticscholar   +1 more source

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Improving Pacing in Long-Form Story Planning [PDF]

arXiv, 2023
Existing LLM-based systems for writing long-form stories or story outlines frequently suffer from unnatural pacing, whether glossing over important events or over-elaborating on insignificant details, resulting in a jarring experience for the reader. We propose a CONCrete Outline ConTrol (CONCOCT) system to improve pacing when automatically generating ...
arxiv  

Walking Pace Is Associated with Lower Risk of All-Cause and Cause-Specific Mortality

Medicine & Science in Sports & Exercise, 2019
Purpose Walking pace is associated with all-cause and cardiovascular disease (CVD) mortality. Whether this association extends to other health outcomes and whether it is independent of total amount of time walked are currently unknown. Therefore, the aim
C. Celis-Morales, S. Gray, F. Petermann, S. Iliodromiti, P. Welsh, D. Lyall, Jana J. Anderson, P. Pellicori, D. Mackay, J. Pell, N. Sattar, J. Gill   +11 more
semanticscholar   +1 more source

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

The NASA Plankton, Aerosol, Cloud, ocean Ecosystem (PACE) mission: an emerging era of global, hyperspectral Earth system remote sensing

Remote Sensing, 2019
The Plankton, Aerosol, Cloud, ocean Ecosystem (PACE) mission represents NASA’s next investment in satellite ocean color and the study of Earth’s ocean-atmosphere system, enabling new insights into oceanographic and atmospheric responses to Earth's ...
E. Gorman, D. Kubalak, Patel Deepak, A. Dress, D. B. Mott, G. Meister, J. Werdell   +6 more
semanticscholar   +1 more source