Results 111 to 120 of about 1,511,256 (261)
Experimental Physiology, EarlyView.Abstract Hyperpolarization‐activated, cyclic nucleotide‐gated (HCN) channels are important regulators of cardiac pacemaking and neuronal excitability, yet their temperature dependence has not been compared systematically across mammalian isoforms and species in standardized experimental conditions. Here, we performed a standardized electrophysiological
Rajnish Ranjan +5 more
wiley +1 more source
The National Security Commission on Artificial Intelligence
, 2021 Website documenting the work of the National Security Commission on Artificial Intelligence, including their final report regarding recommendations for advancement and national security related to "artificial intelligence, machine learning, and ...
National Security Commission on Artificial Intelligence (U.S.)
core
The Journal of Physiology, EarlyView.Abstract figure legend In this study, we use human‐induced pluripotent stem cell‐derived cardiomyocyte (hiPSC‐CM) experiments and computational modelling to identify the mechanism of action of drug compounds. In the hiPSC‐CM experiments, optical measurements of cell collections are recorded in the baseline case and after drug exposure.
Karoline Horgmo Jæger +4 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Immunohistochemistry, electrophysiology and pharmacology are useful tools for understanding protein and channel expression and physiological reactions of calcium‐activated chloride channels (CaCCs). Conventional transmission electron microscopy has provided useful 2‐D information on organelle arrangement, localization and ...
Hiromi Tamada
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend The calcium‐activated chloride (ClCa) channel TMEM16A (also known as ANO1) plays critical roles in ion transport, neurotransmission and smooth muscle contraction. Dysregulation of TMEM16A channel activity contributes to the development and progression of various diseases.
Hisao Yamamura +4 more
wiley +1 more source
Removal of Transvenous Pacemaker Electrodes under Cardiopulmonary Bypass [PDF]
, 1998 We report a patient in whom removal of transvenous pacemaker electrodes under cardiopulmonary bypass was successfully performed. The patient was a 75-year-old man who had undergone unsuccessful surgical treatments eight times followed by development of ...
Kusaba, Eisuke
core
Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes
The Journal of Physiology, EarlyView.Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière +6 more
wiley +1 more source
Cardiac Device Algorithms for Optimal Outcomes in Patients with Sick Sinus Syndrome [PDF]
, 2013 Sick sinus syndrome (SSS) is a relatively common chronic condition affecting the electrical conduction system of the heart. In the absence of any reversible cause of SSS, the most effective treatment is implantation of a permanent pacemaker to maintain ...
CURRY, JANE,KATHERINE
core
International Journal of Cancer, Volume 159, Issue 8, Page 1873-1883, 15 October 2026.ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers due to its asymptomatic progression, late‐stage diagnosis, and treatment resistance. Efforts in early detection have centered on identifying imaging features and liquid biopsy biomarkers capable of detecting PDAC and its high‐grade precursors before clinical symptoms ...
Christine Worthington +105 more
wiley +1 more source
مجله دانشکده پزشکی اصفهان, 2017 Background: Active lead implantation can create injury in myocardium that may be associated with a ST-segment elevation. This ST-segment elevation may be correlated with changes in other parameters such as threshold, sense, amplitude, impedance, and ...
Sima Sayah +2 more
doaj