Results 101 to 110 of about 186,524 (347)

Calsequestrin 2 deletion causes sinoatrial node dysfunction and atrial arrhythmias associated with altered sarcoplasmic reticulum calcium cycling and degenerative fibrosis within the mouse atrial pacemaker complex1.

open access: yesEuropean Heart Journal, 2015
AIMS Loss-of-function mutations in Calsequestrin 2 (CASQ2) are associated with catecholaminergic polymorphic ventricular tachycardia (CPVT). CPVT patients also exhibit bradycardia and atrial arrhythmias for which the underlying mechanism remains unknown.
A. Glukhov   +10 more
semanticscholar   +1 more source

Development of the occipitopetrosal junctions: A histological study using human fetuses

open access: yesThe Anatomical Record, EarlyView.
Abstract The temporal bone petrosa is connected to the occipital bone at two sites: one junction with the basilar part (medial junction) and another with the lateral part (lateral junction). Using histological specimens from 45 human fetuses (approximately 7–39 weeks of gestational age or GA), we aimed to describe possible changes in histology and ...
Ai Hirano‐Kawamoto   +6 more
wiley   +1 more source

Transcription factor ISL1 is essential for pacemaker development and function.

open access: yesJournal of Clinical Investigation, 2015
The sinoatrial node (SAN) maintains a rhythmic heartbeat; therefore, a better understanding of factors that drive SAN development and function is crucial to generation of potential therapies, such as biological pacemakers, for sinus arrhythmias. Here, we
Xingqun Liang   +23 more
semanticscholar   +1 more source

Pacemaker dependency after pacemaker implantation.

open access: yesCardiology journal, 2007
Pacemaker dependency (PD) can be defined as the risk of serious injury or death from sudden pacemaker failure, an event more dangerous than progressive rate decrease. The aim of this study was to evaluate the incidence of PD during long-term follow-up after pacing system implantation.The study included 3638 patients (mean age 65.3 +/- 10.2 years ...
Lelakowski, Jacek   +4 more
openaire   +2 more sources

Fresh insights into the light‐induced pineal gland circadian rhythm transmission mechanism derived from mRNA and miRNA profiling

open access: yesAnimal Research and One Health, EarlyView.
Mechanisms of light in regulating the chick pineal clock. Abstract The circadian clock significantly impacts animal health and productivity, with light playing a crucial role in regulating circadian rhythms. However, the mechanisms behind light‐induced circadian transmission remain unclear, particularly in light‐sensitive avian species.
Yunlei Li   +10 more
wiley   +1 more source

B cells and systemic sclerosis interstitial lung disease

open access: yesArthritis &Rheumatology, Accepted Article.
Interstitial lung disease is an important complication of systemic sclerosis (SSc‐ILD) with high mortality and morbidity. Recent clinical studies in SSc‐ILD have led to FDA‐approved therapies in SSc‐ILD. Importantly, evidence from these studies has been extrapolated to guide management of interstitial lung diseases of other systemic autoimmune ...
Nina Goldman   +2 more
wiley   +1 more source

What Epigenetics Teaches Us About Neuron–Glioma Interactions

open access: yesBioEssays, EarlyView.
Neuron–glioma interactions through the epigenetic lens. Rewiring of epigenetic mechanisms, including alterations in the enhancer landscape and 3D chromatin organization, allows glioma cells to sense and respond to neural signals. Targeting the epigenetic machinery that facilitates this neuron–glioma crosstalk provides a strategy to disrupt the neural ...
Chaitali Chakraborty   +2 more
wiley   +1 more source

Açık kalp cerrahisinde geçici epikardiyal pacemaker tellerinin kullanılmasının klinik önemi

open access: yesGenel Tıp Dergisi, 2015
Amaç: Açık kalp cerrahisi sırasında ve sonrasında geçici epikardiyal pacemaker desteği gerekebilmektedir. Bu çalışmanın amacı; erişkin açık kalp cerrahisinde pacemaker gereksinimi oluşturabilecek faktörlerin tespiti ve kullanım endikasyonlarının ...
Fatih Tomrukçu   +2 more
doaj  

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