Results 81 to 90 of about 1,919,129 (250)

Exposure‐adjusted safety and efficacy of GLP‐I and GLP‐1/GIP receptor agonists compared with non‐GLP‐I for weight management and type 2 diabetes: Based on FDA medical and statistical reports of 34 280 safety and 36 312 efficacy subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to contextualize glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists safety and efficacy regarding weight management (WM); we analysed Food and Drug Administration (FDA) Medical Reviews to analyse 14 medications using patient‐exposure year normalization and ...
Aishwarya Prasad, Anshu Arora, Arun Arora, Jeena Vaid, Arif Khan   +4 more
wiley   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

A mechanism for decadal climate variability

, 1996
We describe in this paper a mechanism for decadal climate variability that can lead to decadal climate cycles in the North Pacific and North Atlantic Oceans. A hierarchy of numerical models and observations are used to understand the fundamental dynamics
Venzke, S. (Max-Planck-Institut fuer Meteorologie, Hamburg (Germany)), Maier-Reimer, E., Muennich, M., Latif, M., Max-Planck-Institut fuer Meteorologie, Hamburg (Germany), Groetzner, A., Barnett, T.P. (Scripps Institution of Oceanography, La Jolla, CA (United States). Climate Research Div.)   +6 more
core  

Analysis of clinical investigation (device) initial submissions received by the Medicines and Healthcare products Regulatory Agency between January 2022 and December 2025

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to analyse clinical investigation‐device initial submissions received by the MHRA between January 2022 and December 2025. Methods Data on submissions were extracted from the clinical investigations unit data bank; software as medical devices were not included. The predefined primary end‐point was submission type.
Andrea Manfrin, Mark Grumbridge, Daniel Hill, Crina Cacou, Graham Warren, James Pound, Jacob George, Alejandro F. Frangi   +7 more
wiley   +1 more source

Modulation of western North Pacific tropical cyclone decadal variability by the Victoria mode

Environmental Research Letters
Intense tropical cyclones (TCs) in the southeastern western North Pacific (SE-WNP) significantly impact East Asian coastal nations. Decadal variability in TC genesis frequency (TCGF) has been linked to the Pacific decadal oscillation (PDO), a major sea ...
Tao Wen, Jianping Li, Shifei Tu, Ruiqiang Ding, Quanjia Zhong, Xumin Li   +5 more
doaj   +1 more source

Response of North Pacific and North Atlantic decadal variability to weak global warming

Advances in Climate Change Research, 2018
The Pacific Decadal Oscillation (PDO) and the Atlantic Multidecadal Variability (AMV) are the two dominant low-frequency modes in the climate system. This research focused on the response of these two modes under weak global warming.
Sheng Wu, Zheng-Yu Liu, Jun Cheng, Chun Li   +3 more
doaj   +1 more source

Bourdieu in Aotearoa New Zealand: A systematic review of theoretical applications in educational research, 2000–2025

British Educational Research Journal, EarlyView.
Abstract This article presents the first systematic review of scholarship applying Pierre Bourdieu's theoretical framework in New Zealand educational research, drawing on 30 peer‐reviewed studies published between 2000 and 2025. Following PRISMA guidelines, studies were coded for Bourdieusian concepts applied, depth of theoretical application ...
Liuning Yang
wiley   +1 more source

Review of the fauna associated with wild and farmed mussels and oysters in the Mediterranean

Biological Reviews, EarlyView.
ABSTRACT Mussels and oysters are important ecosystem engineers which modify the physical and chemical characteristics of the environment and create habitats that support highly diverse associated communities. In the Mediterranean Sea, the native Mediterranean mussel Mytilus galloprovincialis and the European flat oyster Ostrea edulis, together the ...
Barbara Mikac, Marina Antonia Colangelo, Alessandro Tarullo, Marco Abbiati, Eugenio Fossi, Federica Costantini   +5 more
wiley   +1 more source

Distinct effects of interdecadal Warm Pool Seesaw and Interdecadal Pacific Oscillation over the tropical Indo-Pacific

Geoscience Letters
Decadal variability in the tropical Indo-Pacific complicates precipitation projections. Here, we quantify the influence of newly identified Warm Pool Seesaw (WPS) and traditional Interdecadal Pacific Oscillation (IPO) using large ensembles from the ...
Qiwei Sun, Yan Du
doaj   +1 more source

Carrion ecology: concepts, interdisciplinary synthesis, and perspectives

Biological Reviews, EarlyView.
ABSTRACT Carrion is a ubiquitous resource in both terrestrial and aquatic ecosystems, yet it has long been overlooked in ecological research. Over the past two decades, studies on carrion and the many organisms that exploit it have flourished, revealing not only wide‐ranging ecological functions but also significance far beyond ecology.
Marcos Moleón, José A. Sánchez‐Zapata, Travis L. DeVault, Wayne M. Getz, Zebensui Morales‐Reyes, Daniel Redondo‐Gómez, Lara Naves‐Alegre, Solange A. Batista‐Nunes, Esther Sebastián‐González, Juan M. Pérez‐García, Kelly A. Waters, Thijs van Overveld, Craig Smith, Nuria Selva, Thomas A. Schlacher, Graeme Ruxton, Jesús Rodríguez, Martina‐M. Quaggiotto, Paula L. Perrig, Norman Owen‐Smith, Thomas M. Newsome, Isabel Navas, Yoshihiro Nakashima, Ana Mateos, Carlos Martínez‐Carrasco, Daniel Martín‐Vega, Berta Martín‐López, Antoni Margalida, Sergio A. Lambertucci, Adam Kane, Kevin Healy, Akane Hashizume, Antonio J. García‐Fernández, José A. Donázar, M. Eric Benbow, James C. Beasley, Philip S. Barton, Kathleen A. Alexander, Eneko Arrondo   +38 more
wiley   +1 more source