Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
A Randomized Controlled Study Comparing Patient Satisfaction and Clinical Outcomes of Different Nasal Packs in Nasal Surgery. [PDF]
Singh AP, Singh S, Kumar D, Gupta R.
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Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
High-Pressure Inelastic Neutron Spectroscopy: Experimental Validation of Machine-Learned Interatomic Potential Energy Landscapes. [PDF]
Armstrong J, Jackson A, Elena A.
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Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley +1 more source
Hidden ruptured internal carotid artery aneurysm causing occult epistaxis, melena, syncope, and hemodynamic collapse: a case report. [PDF]
Alamir HIA, Alotaibi N.
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Influence Mechanism of Multicomponent Co-adsorption Behavior on the Stability of Oil-Water Interfaces in Shear Flow Fields: Insights from the Microscale. [PDF]
Wang Z, Xu Y, Zhang H, Ismailov AA.
europepmc +1 more source
Active Particles in Tunable Compressible Environments. [PDF]
Tanuku VMSG +5 more
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