Results 91 to 100 of about 179,193 (249)
Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription
FEBS Open Bio, EarlyView.In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang +10 more
wiley +1 more source
Sphere Packing Proper Colorings of an Expander Graph
IEEE Transactions on Information Theory23 pages, 2 ...
openaire +4 more sources
On the Packing Coloring Gap of Graphs
The packing chromatic number of a graph is the minimum number of colors for which the graph admits a packing coloring. This distance-based parameter may change under local structural modifications of the graph. In this paper, we introduce the packing coloring gap, defined as the maximum decrease in the packing chromatic number caused by the deletion of
Tarhini, Batoul, Gözüpek, Didem
openaire +2 more sources
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
Fast algorithm for $S$-packing coloring of Halin graphs
CoRRMotivated by frequency assignment problems in wireless broadcast networks, Goddard, Hedetniemi, Hedetniemi, Harris, and Rall introduced the notion of $S$-packing coloring in 2008. Given a non-decreasing sequence $S = (s_1, s_2, \ldots, s_k)$ of positive integers, an $S$-packing coloring of a graph $G$ is a partition of its vertex set into $k$ subsets $\
Xin Zhang 0017, Dezhi Zou
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Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
FEBS Open Bio, EarlyView.Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
On-line bin-packing problem : maximizing the number of unused bins [PDF]
In this paper, we study the on-line version of the bin-packing problem. We analyze the approximation behavior of an on-line bin-packing algorithm under an approximation criterion called differential ratio.
Marc Demange +2 more
core
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source