Results 91 to 100 of about 148,619 (281)
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
On symplectic packing problems in higher dimensions
Mathematische AnnalenAbstract Let $$B^{2n}(R)$$ denote the closed 2n-dimensional symplectic ball of area R, and let $$\Sigma _g(L)$$ be a closed symplectic surface of genus g and area L. We prove that there is a symplectic embedding $$\bigsqcup \nolimits _{i=1}^k B^4(R_i) \times \Sigma _g (L) \
Kyler Siegel, Yuan Yao
openaire +3 more sources
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Defence TechnologyTwo-dimensional energetic materials (2DEMs), characterized by their exceptional interlayer sliding properties, are recognized as exemplar of low-sensitivity energetic materials.
Xiaokai He +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
On distance sets, box-counting and Ahlfors-regular sets
Discrete Analysis, 2017 On distance sets, box-counting and Ahlfors-regular sets, Discrete Analysis 2017:9, 22 pp. A well-known problem of Falconer, a sort of continuous analogue of the Erdős distinct-distance problem, asks how large the Hausdorff dimension of a Borel subset of
Pablo Shmerkin
doaj +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Hardness and Approximability of Dimension Reduction on the Probability Simplex
AlgorithmsDimension reduction is a technique used to transform data from a high-dimensional space into a lower-dimensional space, aiming to retain as much of the original information as possible.
Roberto Bruno
doaj +1 more source