Results 211 to 220 of about 325,035 (334)

Correction for Spirandelli et al., Exotic self-assembly of hard spheres in a morphometric solvent. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

Bayesian machine learning for inverse design of ultra-high-performance concrete. [PDF]

Philos Trans A Math Phys Eng Sci
Childs C, Miller A, Neiswanger W, Poczos B, Stewart L, Kurtis K, Washburn N.   +6 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Measuring the Impact of Meat Packing and Processing Facilities in Nonmetropolitan Counties: A Difference‐in‐Differences Approach

, 2007
Georgeanne M. Artz, Peter F. Orazem, Daniel Otto   +2 more
openalex   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

New measures for estimating surface complementarity and packing at protein–protein interfaces

, 2010
Pralay Mitra, Debnath Pal
openalex   +1 more source

Cholesterol modulates membrane elasticity via unified biophysical laws. [PDF]

Nat Commun
Kumarage T, Gupta S, Morris NB, Doole FT, Scott HL, Stingaciu LR, Pingali SV, Katsaras J, Khelashvili G, Doktorova M, Brown MF, Ashkar R.   +11 more
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Using Cube Coarse Aggregate to Determine the Compressive Strength of Concrete by Measuring Packing Density and Using Indian Standard and ACI Methods with Variations of Testing Age and Cement Products

Trinugroho Suhendro, Ryan Adi Nugroho
openalex   +1 more source

Recapturing Cooperativity of α-Helix Formation and Packing in Coarse-Grained Protein Structure Modeling with Multitorsional Potentials. [PDF]

J Phys Chem B
Petrusevich EF, Liwo A.
europepmc   +1 more source