Results 21 to 30 of about 38,225 (264)

Cellular inhibitor of apoptosis (cIAP)-mediated ubiquitination of phosphofurin acidic cluster sorting protein 2 (PACS-2) negatively regulates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity. [PDF]

PLoS ONE, 2014
Lysosomal membrane permeabilization is an essential step in TRAIL-induced apoptosis of liver cancer cell lines. TRAIL-induced lysosomal membrane permeabilization is mediated by the multifunctional sorting protein PACS-2 and repressed by the E3 ligases ...
Maria Eugenia Guicciardi, Nathan W Werneburg, Steven F Bronk, Adrian Franke, Hideo Yagita, Gary Thomas, Gregory J Gores   +6 more
doaj   +1 more source

Discrete Characterization of Domain Using Semantic Clustering

Journal of Advances in Information Technology, 2010
Lots of approaches have been developed to understand the software source code and majority of them are focused on program structural information which results in the loss of domain semantic crucial information contained in the text or symbols of source ...
Sanjay Madan, Shalini Batra
doaj   +1 more source

Combining Register and Radiological Visits Data Allows to Reliably Identify Incident Wrist Fractures

Clinical Epidemiology, 2023
Tomi Nissinen,1,2 Reijo Sund,3 Sanna Suoranta,2,4 Heikki Kröger,3,5 Sami P Väänänen1,2 1Department of Technical Physics, University of Eastern Finland, Kuopio, Finland; 2Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland ...
Nissinen T, Sund R, Suoranta S, Kröger H, Väänänen SP   +4 more
doaj  

Dysregulations in hemostasis, metabolism, immune response, and angiogenesis in post-acute COVID-19 syndrome with and without postural orthostatic tachycardia syndrome: a multi-omic profiling study

Scientific Reports, 2023
Post-acute COVID-19 (PACS) are associated with cardiovascular dysfunction, especially postural orthostatic tachycardia syndrome (POTS). Patients with PACS, both in the absence or presence of POTS, exhibit a wide range of persisting symptoms long after ...
Ali Mahdi, Allan Zhao, Emelie Fredengren, Artur Fedorowski, Frieder Braunschweig, Malin Nygren-Bonnier, Michael Runold, Judith Bruchfeld, Jannike Nickander, Qiaolin Deng, Antonio Checa, Liyew Desta, John Pernow, Marcus Ståhlberg   +13 more
doaj   +1 more source

PACS adoption

Seminars in Roentgenology, 2003
Once the decision has been made to adopt PACS instead of a film-based radiology practice, there are a number of hurdles to jump. Users need to be aware of the impact the change will make on end users and be prepared to address issues that arise before they become problems.
Department of Radiology, University of Florida, Gainesville, FL, USA ( host institution ), Honeyman-Buck, Janice   +1 more
openaire   +3 more sources

Influence of smoking on cardiac structural and functional remodeling patterns in unstable angina and post-COVID-19 patients

Zaporožskij Medicinskij Žurnal
Aim. To assess the structural and functional myocardial characteristics in patients with unstable angina (UA) and post-COVID-19 syndrome (PACS), stratified by smoking status. Materials and methods.
Kh. M. Khamuliak , T. M. Solomenchuk
doaj   +1 more source

Microbiome and mycobiome cross-talk from an immunobiotic perspective in COVID-19 and post-acute COVID-19 syndrome [PDF]

Exploration of Immunology
Coronavirus disease 2019 (COVID-19) infected individuals showed either mild symptoms or were paucisymptomatic, with severe impact on human health, revealing heightened risk and direct effects on health. Among various factors contributing to complications,
Sunny Kumar, Zeel Bhatia, Sriram Seshadri   +2 more
doaj   +1 more source

Tuning Mechanoreceptor Signaling Enhances the Adjuvant Effect of Biomaterial Vaccines

Advanced Functional Materials, EarlyView.
Matrix stiffness serves as an independent immunological signal in biomaterial vaccines. Stiffer microporous hydrogel vaccines enhance dendritic cell maturation and migration to draining lymph nodes, promote T follicular helper cell expansion through Yap/Taz signaling, and increase antigen‐specific antibody production.
Lily Shang, Daniel P. Mayer, Prabhat K. Purbey, Yingzi Liu, Kindra Kelly‐Scumpia, Clara Kang, Natalie Tsubamoto, Dhriti Bolangadi, Iqra Arshad, Charisse Ng, Maksim V. Plikus, Dino Di Carlo, Jason S. Weinstein, Philip O. Scumpia   +13 more
wiley   +1 more source

Multilayered Digital Microfluidic Chip for Cell‐Based Assays

Advanced Materials Interfaces, EarlyView.
A multilayered digital microfluidic (mDMF) chip architecture is introduced to improve throughput and robustness in cell‐based assays. By multilayering electrode components and dielectric layers on glass, this design significantly reduces actuation voltage, maintains reliability, and enables expansion of the operational area with minimum current leakage.
Mert Ozden, Oksana K. Savchak, Burcu Gumuscu   +2 more
wiley   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source