Results 241 to 250 of about 342,129 (316)

Scaling Up Is Not the Same but Bigger: Overcoming (Some) Limitations in Enzymatic Decarboxylations in Rotating Bed Reactors in Deep Eutectic Solvents. [PDF]

Org Process Res Dev
Vaupel S, Meyer LE, Domínguez de María P, Kara S.   +3 more
europepmc   +1 more source

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

A Comparison of a Customized Peripheral Artery Disease (PAD)-Specific Generative AI Chatbot and General-Purpose AI Chatbots for PAD Patient Education. [PDF]

J Clin Med
Cherif A, Alagna ME, Reilly MA, Lopes L, Crutcher M, Schroeder J, Carey KA, Brahmandam A, Liebovitz D, Ho KJ.   +9 more
europepmc   +1 more source

Covalent Inhibition of SHMT2 by Gambogic Acid Induces Ferroptosis Through Mitochondrial Collapse in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In this study, chemoproteomics combined with genetic and functional analyses was integrated to identify SHMT2 as a covalent and functional target of gambogic acid (GA) in triple‐negative breast cancer (TNBC). Further validation demonstrated that GA selectively modifies the Cys241 site of SHMT2, triggering mitochondrial dysfunction, activating the Nrf2 ...
Tong Yang, Chong Qiu, Yulei Li, Ying Zhang, Chen Wang, Jie Zhou, Zheng Chu, Ang Ma, Ling Huang, Yin Kwan Wong, Junzhe Zhang, Peng Gao, Cui Liu, Junhua Zhang, Huan Tang, Jigang Wang   +15 more
wiley   +1 more source

National, regional and provincial prevalence of peripheral artery disease in Chinese adults in 2023: an updated systematic review and modelling study. [PDF]

J Glob Health
Zhou J, Shan S, Shen G, Tan B, Ying J, Rudan I, Song P, Global Health Epidemiology Research Group (GHERG).   +7 more
europepmc   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Peripheral artery disease in diabetes. [PDF]

Front Endocrinol (Lausanne)
Amin S, Fukaya E, Athavale A.
europepmc   +1 more source

PAD [PDF]

, 2019
openaire   +1 more source

Evaluating the Tissue Optical Perfusion Pressure Method in Diabetic Patients with and Without Media Arterial Calcification. [PDF]

J Clin Med
Kalaja I, Meertens MM, Schmitt VH, Linnemann B, Weißer G, Schwaderlapp M, Schneider S, Hoffmann L, Espinola-Klein C.   +8 more
europepmc   +1 more source