Results 41 to 50 of about 342,129 (316)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Foods, 2023 Emulsion gels are gaining interest as fat replacers due to their benefits associated with calorie reduction and their versatility in a wide range of products.
Marcello Alinovi +5 more
doaj +1 more source
Influence of Process Parameters on the Deformation of Copper Foils in Flexible-Pad Laser Shock Forming [PDF]
, 2013 This paper investigates a new microforming technique, Flexible-Pad Laser Shock Forming (FPLSF), to produce mi-crofeatures on metallic foils without rigid punches and dies.
Castagne, Sylvie +2 more
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Design of U-Geometry Parameters Using Statistical Analysis Techniques in the U-Bending Process
Metals, 2017 The various U-geometry parameters in the U-bending process result in processing difficulties in the control of the spring-back characteristic. In this study, the effects of U-geometry parameters, including channel width, bend angle, material thickness ...
Wiriyakorn Phanitwong +2 more
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Effect of pad water flow rate on evaporative cooling system efficiency in laying hen housing
Journal of Agricultural Engineering, 2020 An experiment was conducted in three commercial laying hen houses with 32-week-old hens in the summer of 2017 in a commercial farm in Gharbia Province, Egypt (31.06ºN, 31.16ºE) using an evaporative pad cooling system to determine the most suitable water ...
Mohamed Saied Ghoname
doaj +1 more source
Genetics, Immunity and Nutrition Boost the Switching from NASH to HCC
Biomedicines, 2021 Nonalcoholic fatty liver disease (NAFLD) is the leading contributor to the global burden of chronic liver diseases. The phenotypic umbrella of NAFLD spans from simple and reversible steatosis to nonalcoholic steatohepatitis (NASH), which may worsen into ...
Paola Dongiovanni +4 more
doaj +1 more source
MiR‐513a promotes human erythroid differentiation by modulating c‐Jun
FEBS Open Bio, EarlyView.During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim +11 more
wiley +1 more source