Results 141 to 150 of about 123,268 (305)
Cerebral function monitoring in term or near term neonates at MDH : preliminary experience and proposal of a guideline [PDF]
, 2012 Introduction: Cerebral function monitoring (CFM) is a simplified EEG device that is used to monitor cerebral function at the cot-side. Various studies have shown its value in detecting neonatal encephalopathy and electrographic seizures, prognostication ...
Attard, Stephen +2 more
core
Advanced Science, EarlyView.Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong +24 more
wiley +1 more source
Advanced Science, EarlyView.This review examines the evolution of bioprinting toward minimally invasive in situ strategies for internal organ regeneration. It defines the technological roadmap from handheld systems to advanced minimally invasive bioprinting platforms, positioning soft robotics as a core enabler.
Duc Tu Vu +9 more
wiley +1 more source
Deciphering the Impact of RAC1‐SPTAN1 in ARPKD Cystogenesis Using Multifaceted Models
Advanced Science, EarlyView.Distal/connecting tubules expressing SLC8A1 have been suggested as a potential origin of ARPKD cysts. SPTAN1 has been identified as a key molecule in ARPKD cyst formation. Restoring SPTAN1 in PKHD1−/− organoids reduced cyst formation, normalized calcium levels, and decreased RAC1/c‐FOS expression, highlighting SPTAN1's role in ARPKD and the potential ...
Shohei Kuraoka +9 more
wiley +1 more source
Annals of Gastroenterological Surgery, EarlyView.In hepatocellular carcinoma treated with atezolizumab–bevacizumab, responders showed RNA‐seq enrichment of immune and chemokine pathways with higher HAMP expression. In resected specimens, immunohistochemistry confirmed increased intratumoral CD8+ T‐cell density and hepcidin (HAMP), supporting HAMP plus CD8 as components of a composite predictor of ...
Shun Nakamura +9 more
wiley +1 more source
Deep Learning‐Assisted Coherent Raman Scattering Microscopy
Advanced Intelligent Discovery, EarlyView.The analytical capabilities of coherent Raman scattering microscopy are augmented through deep learning integration. This synergistic paradigm improves fundamental performance via denoising, deconvolution, and hyperspectral unmixing. Concurrently, it enhances downstream image analysis including subcellular localization, virtual staining, and clinical ...
Jianlin Liu +4 more
wiley +1 more source
Advanced Intelligent Systems, EarlyView.During lengthy minimally invasive surgeries, fatigue can cause surgeon tremor and poor endoscopic coordination. This study proposes a robot‐assisted endoscopic adjustment system. It employs a lightweight instrument detection model and a hierarchical multiconstraint controller for visual servoing.
Zijie Yang +5 more
wiley +1 more source
Microrobotic Catheterization of the Ophthalmic Artery for Targeted Treatment of Retinoblastoma
Advanced Intelligent Systems, EarlyView.A microrobotic platform is presented that allows teleoperated and autonomous navigation of flow‐driven magnetic microcatheters, MagFlow, into the ophthalmic artery for superselective intra‐arterial infusion of chemotherapy to treat retinoblastoma. Extensive benchtop validations with patient‐derived biomimetic phantoms under optical and fluoroscopic ...
Artur Banach +5 more
wiley +1 more source
Genetic Contribution to Asthma Informs Acute Chest Syndrome Pathophysiology and Risk Stratification
American Journal of Hematology, EarlyView.ABSTRACT Acute chest syndrome (ACS) is a severe complication of sickle cell disease (SCD) occurring in ~50% of patients, some presenting frequent episodes. We lack tools to identify patients at high risk of ACS occurrence or frequent episodes. Epidemiological studies have found an association between asthma and ACS, but whether this link is causal is ...
Sara El Aouhel +10 more
wiley +1 more source
American Journal of Hematology, EarlyView.ABSTRACT Mantle cell lymphoma (MCL) is a B‐cell malignancy with a chronically relapsing clinical course and pronounced genetic heterogeneity. To investigate the clonal dynamics underlying early disease relapse, we performed single‐cell RNA sequencing of paired tumor samples collected at diagnosis and at first relapse. Inference of copy number variants (
Dmitry Manakov +14 more
wiley +1 more source