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Immunohistochemical study of mammary and extra‐mammary Paget's disease [PDF]
Paraffin sections of 13 cases of Paget's disease (six mammary and seven extramammary) were investigated with mono‐ and polyclonal anti‐carcinoembryonic antigen (CEA) and with monoclonal anti‐human milk fat globule membrane antigen (HMFG). One of these cases was also analysed in cryostat sections with monoclonal anti‐cytokeratin and anti‐keratin.
M J, Vanstapel +5 more
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Underlying pathology in mammary Paget's disease
Annals of Surgical Oncology, 1997Management of patients with mammary Paget's disease is controversial; recent recommendations range from primary radiotherapy to modified radical mastectomy. This review correlates associated breast findings with disease stage and outcome to help guide evaluation and treatment.Retrospective review of clinical, mammographic and pathologic data from 38 ...
J H, Yim +4 more
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The histogenesis of mammary and extramammary Paget's disease
Histopathology, 1989The histogenesis of mammary and extramammary Paget's disease has been studied by immunohistochemical staining of paraffin‐embedded tissue using a panel of epithelial cell markers, which react with secretory or ductal epithelium, but not stratified epithelium.
R R, Jones, J, Spaull, B, Gusterson
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Mammary and Extramammary Paget's Disease
Australasian Journal of Dermatology, 1974SUMMARYTwo cases of mammary and one case of vulval Paget's disease are studied histologically and electronmicroscopically. There are no substantial morphological differences between those two types.The Paget cell has a characteristic fine structure: it lacks tonofibrils and shows many of the features of apocrine cells.
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Replication of Paget cells in mammary and extramammary Pages disease
British Journal of Dermatology, 1984Replication of Paget cells in mammary and extramammary Paget's disease was evaluated by autoradiography after incorporation of tritiated thymidine. Neoplastic cells proliferated in the deepest layers of the epidermis suggesting a topographical control of their multiplication similar to that of the normal epidermis.
C, Pierard-Franchimont, G E, Pierard
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[Extra Mammary Paget disease].
Annales de pathologie, 2022Extramammary Paget's disease is a rare malignancy. The underlying cause of VPD remains not well understood. We provide an overview of the histopathology of vulvar Paget's disease, with or without invasion.
Isabelle, Moulonguet +1 more
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Mammary Paget Disease in Darier Disease
The American Journal of Dermatopathology, 2012This case describes new onset mammary Paget disease arising in the background of Darier disease. Clinically and histologically, lesions of Darier disease can mask the lesions of mammary Paget disease. A high index of suspicion is necessary to diagnose Paget disease in a patient with Darier disease, for a potentially fatal disease could easily be missed.
Amy, Spizuoco +4 more
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Mammary and extramammary Pagetʼs disease
The American Journal of Dermatopathology, 1985Ten cases of mammary Paget's disease and 10 cases of extramammary Paget's disease were studied for differences of histologic features in them. Based on the epidermal changes alone, Paget cells in 90% of specimens from lesions of extramammary Paget's disease had abundant mucin that stained well, whereas Paget cells in only 40% of specimens from mammary ...
C, Sitakalin, A B, Ackerman
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Pigmented spots as a sign of mammary Paget’s disease
Clinical and Experimental Dermatology, 2009Pigmented mammary Paget's disease is a rare variant of mammary Paget's disease. The clinical appearance mimics malignant melanoma. This paper describes a case of asymptomatic, slightly pigmented spots on the right mammary nipple. The pigmented nipple was histopathologically diagnosed as mammary Paget's disease with an underlying intraductal carcinoma ...
N, Oiso, S, Kawara, H, Inui, A, Kawada
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