Results 1 to 10 of about 11,714 (178)

Updates on Paget’s Disease of Bone [PDF]

Endocrinology and Metabolism, 2022
Paget’s disease of the bone is a prevalent bone disease characterized by disorganized bone remodeling; however, it is comparatively uncommon in East Asian countries, including China, Japan, and Korea. The exact cause still remains unknown. In genetically
Yong Jun Choi, Young Bae Sohn, Yoon-Sok Chung   +2 more
doaj   +2 more sources

Paget’s Disease of Bone and Normocalcemic Variant of Primary Hyperparathyroidism in an Osteoporotic Male: Exceptional Coexistence [PDF]

Reports
Background and clinical significance: Paget’s disease of bone involves anomalies of the bone metabolism; however, the presence of tumor-derivate abnormal parathyroid hormone (PTH) levels does not represent one of these disturbances. To our best knowledge,
Ana-Maria Gheorghe, Oana Petronela Ionescu, Mihai Costachescu, Oana-Claudia Sima, Mara Carsote   +4 more
doaj   +2 more sources

Epigenetic DNA Methylation Signatures Associated With the Severity of Paget’s Disease of Bone [PDF]

Frontiers in Cell and Developmental Biology, 2022
Background: Paget’s disease of bone (PDB) is characterized by focal areas of dysregulated bone turnover resulting in increased bone loss and abnormal bone formation with variable severity.
Ilhame Diboun, Ilhame Diboun, Sachin Wani, Stuart H. Ralston, Omar M. E. Albagha, Omar M. E. Albagha   +5 more
doaj   +2 more sources

Misdiagnosis of Paget’s Disease of Bone in a Congenital Generalized Lipodystrophy Patient: Case Report [PDF]

Frontiers in Endocrinology, 2021
Paget’s disease of bone (PDB) is a common skeleton disorder in which the diagnosis is suggested by radiological analyses. Congenital generalized lipodystrophy (CGL) is a rare, but a radiologic differential diagnosis of Paget’s disease.
Erika Bastos Lima Freire, Erika Bastos Lima Freire, Erika Bastos Lima Freire, Mayara Ponte Madeira, Mayara Ponte Madeira, Mayara Ponte Madeira, Grayce Ellen da Cruz Paiva Lima, Grayce Ellen da Cruz Paiva Lima, Grayce Ellen da Cruz Paiva Lima, Virginia Oliveira Fernandes, Virginia Oliveira Fernandes, Virginia Oliveira Fernandes, Lindenberg Barbosa Aguiar, João Paulo Uchoa Fontenele, Ana Paula Dias Rangel Montenegro, Thyciara Fontenele Marques, Renan Galvão Ozório, Catarina Brasil d’Alva, Catarina Brasil d’Alva, Catarina Brasil d’Alva, Renan Magalhães Montenegro, Renan Magalhães Montenegro, Renan Magalhães Montenegro   +22 more
doaj   +2 more sources

Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions Analogous to Human Paget’s Disease of Bone [PDF]

Cells, 2023
Paget’s Disease of Bone (PDB) is a metabolic bone disease that is characterized by dysregulated osteoclast function leading to focal abnormalities of bone remodeling. It can lead to pain, fracture, and bone deformity. G protein-coupled receptor kinase 3 (
Emily M. Rabjohns, Rishi R. Rampersad, Arin Ghosh, Katlyn Hurst, Amanda M. Eudy, Jaime M. Brozowski, Hyun Ho Lee, Yinshi Ren, Anthony Mirando, Justin Gladman, Jessica L. Bowser, Kathryn Berg, Sachin Wani, Stuart H. Ralston, Matthew J. Hilton, Teresa K. Tarrant   +15 more
doaj   +2 more sources

Monostotic Paget’s disease of bone – literature review and case report [PDF]

Rheumatology, 2019
Paget’s disease of bone (PDB) is a localized, chronic bone metabolic disorder, characterized by an osteoclastic malfunction, causing increased bone resorption and subsequent compensatory creation of new bone with a defective microstructure.
Piotr Wysiński, Magdalena Krajewska-Włodarczyk   +1 more
doaj   +2 more sources

Prophylactic zoledronic acid therapy to prevent or modify Paget’s disease of bone progression in adults with SQSTM1 mutations: the ZiPP RCT

Efficacy and Mechanism Evaluation
Background Paget’s disease of bone is characterised by focal abnormalities of bone turnover resulting in various complications. It often presents at an advanced stage with irreversible bone damage. At this point, the symptomatic benefits of treatment are
Jonathan Phillips, Deepak Subedi, Steff C Lewis, Catriona Keerie, Stuart H Ralston   +4 more
doaj   +2 more sources

Paget's disease of bone in Tunisia: A study of 69 patients

Indian Journal of Endocrinology and Metabolism, 2020
Context: Paget's disease of bone is a common bone disease with a striking variation in its incidence and characteristics in different parts of the world. It is uncommonly reported in African patients.
Kaouther Maatallah, Safa Rahmouni, Saoussen Miladi, Leila Rouached, Hanen Ferjeni, Alia Fazaa, Ahmed Laatar, Dhia Kaffel, Wafa Hamdi   +8 more
doaj   +1 more source

DIAGNOSIS AND MANAGEMENT OF PAGET'S DISEASE OF BONE - SERIES OF 8 CASES [PDF]

Acta Ortopédica Brasileira, 2019
Paget's disease of bone is a chronic condition characterized by focal abnormalities of absorption and formation of bone, and it may lead to anatomical deformities, pain, fractures, and malignant transformation.
Felipe Augusto Kazan de Oliveira, Fábio Fernando Eloi Pinto, Trajano Sardenberg, Gilberto José Cação Pereira, Emílio Carlos Curcelli, Valter Penna   +5 more
doaj   +1 more source

Molecular effect of an OPTN common variant associated to Paget's disease of bone [PDF]

, 2018
Paget's disease of bone (PDB) is a chronic bone disorder and although genetic factors appear to play an important role in its pathogenesis, to date PDB causing mutations were identified only in the Sequestosome 1 (SQSTM1) gene at the PDB3 locus.
Brown, Jacques P., Cancela, M. Leonor, Conceição, Natércia, Gagnon, Edith, Michou, Laetitia, Silva, Iris   +5 more
core   +6 more sources