Results 31 to 40 of about 11,488 (177)

Paget's disease of the skull causing hyperprolactinemia and erectile dysfunction: a case report

Journal of Medical Case Reports, 2008
Introduction Hyperprolactinemia is an uncommon cause of erectile dysfunction in men. Paget's disease of the skull is a relatively common disease. This case proposes a rare example of a causative link between the two and how treatment of the Paget's ...
Hepherd Rachel, Jennings Paul E
doaj   +1 more source

Paget’s disease of bone: the first case reported in Iraqi Kurdish

Egyptian Rheumatology and Rehabilitation, 2023
Background Paget’s disease of bone (PDB) is a chronic bone disorder which insidiously evolves parallel with the aging process. The affected bone has a distinct imaging appearance, and the clinical manifestations are variable.
Trefa Salih Hasan, Abdulsatar Kamil Faeq
doaj   +1 more source

Multisystem proteinopathy due to a homozygous p.Arg159His VCP mutation : a tale of the unexpected [PDF]

, 2020
ObjectiveTo assess the clinical, radiologic, myopathologic, and proteomic findings in a patient manifesting a multisystem proteinopathy due to a homozygous valosin-containing protein gene (VCP) mutation previously reported to be pathogenic in the ...
Azmi, A, Baets, J, Clemen, CS, De Bleecker, Jan, De Jonghe, P, De Ridder, W, Eichinger, L, Hofmann, A, Johnson, K, Maudsley, S, Schröder, R, Straub, V, Töpf, A   +12 more
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Synchronous osseous metastasis, degenerative changes, and incidental multifocal Paget's disease in a case of newly diagnosed prostatic carcinoma

World Journal of Nuclear Medicine, 2020
Tc-99m methylene diphosphonate bone scintigraphy (bone scan) is a highly sensitive technique for the evaluation of osseous pathology. However, the nonspecificity of the method can present diagnostic challenges in differentiating benign from malignant ...
Robert Devita, Kaushik Chagarlamudi, Arash Kardan   +2 more
doaj   +1 more source

Misdiagnosis of Paget’s Disease of Bone in a Congenital Generalized Lipodystrophy Patient: Case Report

Frontiers in Endocrinology, 2021
Paget’s disease of bone (PDB) is a common skeleton disorder in which the diagnosis is suggested by radiological analyses. Congenital generalized lipodystrophy (CGL) is a rare, but a radiologic differential diagnosis of Paget’s disease.
Erika Bastos Lima Freire, Erika Bastos Lima Freire, Erika Bastos Lima Freire, Mayara Ponte Madeira, Mayara Ponte Madeira, Mayara Ponte Madeira, Grayce Ellen da Cruz Paiva Lima, Grayce Ellen da Cruz Paiva Lima, Grayce Ellen da Cruz Paiva Lima, Virginia Oliveira Fernandes, Virginia Oliveira Fernandes, Virginia Oliveira Fernandes, Lindenberg Barbosa Aguiar, João Paulo Uchoa Fontenele, Ana Paula Dias Rangel Montenegro, Thyciara Fontenele Marques, Renan Galvão Ozório, Catarina Brasil d’Alva, Catarina Brasil d’Alva, Catarina Brasil d’Alva, Renan Magalhães Montenegro, Renan Magalhães Montenegro, Renan Magalhães Montenegro   +22 more
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Cellular and molecular mediators of bone metastatic lesions [PDF]

, 2018
Bone is the preferential site of metastasis for breast and prostate tumor. Cancer cells establish a tight relationship with the host tissue, secreting factors that stimulate or inhibit bone cells, receiving signals generated from the bone remodeling ...
Battafarano, Giulia, Del Fattore, Andrea, Marampon, Francesco, Rossi, Michela   +3 more
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An unusual presentation of metastatic bone disease in a subject with Paget's disease of bone

Journal of Family Medicine and Primary Care, 2016
Solid organ malignancies involving breast, prostate, and lung frequently metastasize to the skeleton. However, the occurrence of Paget's disease and metastatic bone disease in the same patient is uncommon.
Shrinath Shetty, Sahana Shetty, Annie Jennifer Prabhu, Nitin Kapoor, Julie Hepzibah, Thomas Vizhalil Paul   +5 more
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Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions Analogous to Human Paget’s Disease of Bone

Cells, 2023
Paget’s Disease of Bone (PDB) is a metabolic bone disease that is characterized by dysregulated osteoclast function leading to focal abnormalities of bone remodeling. It can lead to pain, fracture, and bone deformity. G protein-coupled receptor kinase 3 (
Emily M. Rabjohns, Rishi R. Rampersad, Arin Ghosh, Katlyn Hurst, Amanda M. Eudy, Jaime M. Brozowski, Hyun Ho Lee, Yinshi Ren, Anthony Mirando, Justin Gladman, Jessica L. Bowser, Kathryn Berg, Sachin Wani, Stuart H. Ralston, Matthew J. Hilton, Teresa K. Tarrant   +15 more
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General analysis of mathematical models for bone remodeling

, 2010
Bone remodeling is regulated by pathways controlling the interplay of osteoblasts and osteoclasts. In this work, we apply the method of generalized modelling to systematically analyse a large class of models of bone remodeling.
Gross, Thilo, Siegmund, Stefan, Stiefs, Dirk, Zumsande, Martin   +3 more
core   +1 more source

The SQSTM1/p62 UBA domain regulates Ajuba localisation, degradation and NF-κB signalling function

PLoS ONE, 2021
The LIM-domain containing protein Ajuba and the scaffold protein SQSTM1/p62 regulate signalling of NF-κB, a transcription factor involved in osteoclast differentiation and survival.
Melanie A. Sultana, Carmel Cluning, Wai-Sin Kwong, Nicole Polain, Nathan J. Pavlos, Thomas Ratajczak, John P. Walsh, Jiake Xu, Sarah L. Rea   +8 more
doaj   +2 more sources