Results 81 to 90 of about 11,488 (177)
Paget’s Disease and Secondary Hyperparathyroidism: Is Healing Possible?
Frontiers in Cell and Developmental Biology, 2020 Paget bone disease (PDB) is often asymptomatic and incidentally diagnosed. It is a cause of osteoporosis and bone fragility and exposes patients to a high incidence of bone fractures.
Vincenzo Antonio Panuccio, Rocco Tripepi
doaj +1 more source
p97 Disease Mutations Modulate Nucleotide-Induced Conformation to Alter Protein-Protein Interactions. [PDF]
, 2016 The AAA+ ATPase p97/VCP adopts at least three conformations that depend on the binding of ADP and ATP and alter the orientation of the N-terminal protein-protein interaction (PPI) domain into up and down conformations.
Arkin, Michelle +2 more
core
Mechanical Competence and Bone Quality Develop During Skeletal Growth. [PDF]
, 2019 Bone fracture risk is influenced by bone quality, which encompasses bone's composition as well as its multiscale organization and architecture. Aging and disease deteriorate bone quality, leading to reduced mechanical properties and higher fracture ...
Amling, Michael +12 more
core +1 more source
A Case Report of Short‐Term Metastasis After Surgery for Mammary Paget's Disease
Clinical Case Reports, Volume 13, Issue 12, December 2025.ABSTRACT Mammary Paget's disease (MPD) with ductal carcinoma in situ (DCIS) pathology can metastasize rapidly. HER2‐positive status likely drives aggression, warranting early postoperative systemic imaging and close surveillance. Anti‐HER2 agents require proactive toxicity management.
Chao Wang +6 more
wiley +1 more source
Boning up on autophagy: the role of autophagy in skeletal biology. [PDF]
, 2013 From an evolutionary perspective, the major function of bone is to provide stable sites for muscle attachment and affording protection of vital organs, especially the heart and lungs (ribs) and spinal cord (vertebrae and intervertebral discs).
Layfield, Robert +4 more
core +2 more sources
First Case of Primary Breast Melanoma in Central America: Case Report and Literature Review
Clinical Case Reports, Volume 13, Issue 12, December 2025.ABSTRACT Primary breast melanoma is an exceedingly rare neoplasm, accounting for < 0.5% of all malignant breast tumors. Its scarcity and highly variable clinical presentation often delay diagnosis and complicate management. We report the case of a 55‐year‐old woman with a primary non‐cutaneous melanoma of the right breast initially misdiagnosed as high‐
Ana García‐Urbina +3 more
wiley +1 more source
Pachydermoperiostosis-Like Disease In Captive Red Ruffled Lemurs (Varecia Variegatus Rubra) [PDF]
, 2011 Pachydermatoperiostosis, a rare form of hypertrophic osteoarthropathy, is of unknown etiology and previously thought limited to humans. The only periosteal reaction previously reported in prosimians is related to renal disease.
Bruce Rothschild +2 more
core +1 more source
Disease Models & Mechanisms, 2022 First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping early-career researchers promote themselves alongside their papers.
doaj +1 more source
Genetic modifiers of cognitive maintenance among older adults. [PDF]
, 2014 ObjectiveIdentify genetic factors associated with cognitive maintenance in late life and assess their association with gray matter (GM) volume in brain networks affected in aging.MethodsWe conducted a genome-wide association study of ∼2.4 M markers to ...
Coppola, Giovanni +5 more
core +1 more source
Paget's Disease of the Bone and Lynch Syndrome: An Exceptional Finding. [PDF]
Diagnostics (Basel), 2023 Gheorghe AM +5 more
europepmc +1 more source