Results 61 to 70 of about 10,354,029 (272)

Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents

Chemistry – A European Journal, EarlyView.
This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley   +1 more source

Spinal localization of Paget disease: Case report [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2008
INTRODUCTION Paget disease, localized on thoracal vertebrae, presents a significant challenge in diagnostics and treatment. Presenting with progressive neurological symptoms, it has a broad differential diagnostic spectrum and requires additional ...
Vukašinović Zoran, Slavković Nemanja, Spasovski Duško, Slavković Slobodan   +3 more
doaj   +1 more source

The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget’s disease

Cell Research, 2020
Mammary and extramammary Paget’s Diseases (PD) are a malignant skin cancer characterized by the appearance of Paget cells. Although easily diagnosed, its pathogenesis remains unknown.
Yongli Song, C. Guerrero-Juarez, Zhongjian Chen, Yichen Tang, Xianghui Ma, Cong Lv, Xueyun Bi, Min Deng, Lina Bu, Yuhua Tian, Ruiqi Liu, Ran Zhao, Jiuzhi Xu, Xiaole Sheng, Sujuan Du, Yeqiang Liu, Yunlu Zhu, Shi-jun Shan, Hong-Duo Chen, Yiqiang Zhao, Guangbiao Zhou, Jianwei Shuai, F. Ren, L. Xue, Zhaoxia Ying, X. Dai, C. Lengner, B. Andersen, M. Plikus, Q. Nie, Zhengquan Yu   +30 more
semanticscholar   +1 more source

One‐year follow‐up after fractionated ultra‐high‐dose‐rate FLASH radiotherapy in patient with extramammary Paget disease of the scrotum

Precision Radiation Oncology, EarlyView.
An elderly male patient with extramammary Paget disease of the scrotum and multiple metastases was treated with fractionated FLASH‐RT (40 Gy in 5 fractions) in the scrotal lesion. Abstract Objective Ultrahigh‐dose‐rate radiotherapy (FLASH‐RT) has been shown to reduce radiation‐induced normal tissue injury in preclinical studies.
Hui Luo, Chengliang Yang, Ronghu Mao, Leijie Ma, Hongchang Lei, Peng Chen, Yanping Zhang, Meng Xu, Chao Wang, Yiwu Wang, Mingxia Wu, Chanjun Sun, Han Liu, Hui Liu, Hong Ge   +14 more
wiley   +1 more source

Diagnosis and Management of Paget's Disease of Bone in Adults: A Clinical Guideline

Journal of Bone and Mineral Research, 2019
An evidence‐based clinical guideline for the diagnosis and management of Paget's disease of bone (PDB) was developed using GRADE methodology, by a Guideline Development Group (GDG) led by the Paget's Association (UK).
S. Ralston, L. Corral-Gudino, C. Cooper, R. Francis, W. Fraser, L. Gennari, N. Guañabens, M. K. Javaid, R. Layfield, T. O’Neill, R. Russell, M. Stone, K. Simpson, D. Wilkinson, R. Wills, M. Zillikens, S. Tuck   +16 more
semanticscholar   +1 more source

Peri‐operative management of diabetes mellitus: a multidisciplinary consensus statement from the Association of Anaesthetists and the Joint British Diabetes Societies for Inpatient Care group

Anaesthesia, EarlyView.
Summary Introduction Surgery in patients with diabetes mellitus is associated with increased morbidity and mortality compared with those who do not have diabetes mellitus. This is likely multifactorial and could be attributed to organisational issues; dysglycaemia; hospital‐acquired diabetic ketoacidosis; errors with insulin prescribing and ...
Nicholas A. Levy, Kariem El‐Boghdadly, Dileep N. Lobo, Daniel J. Stubbs, Parizad Avari, Donal Buggy, Claire Frank, Kim Howson, Jinty Moffett, Emma Morris, Omar G. Mustafa, Glynn Nash, Pádraig Ó Scanaill, Sarah Procter, Gerry Rayman, Kim Russon, Caroline Thomas, Sarah Tinsley, Allan Xu, Ketan Dhatariya   +19 more
wiley   +1 more source

Osteomalacia in a patient with Paget's bone disease treated with long-term etidronate [PDF]

, 2012
SummaryA 93 year-old woman with Paget\u27s disease of bone had been treated with etidronate without interruption during 20 years. The daily dose was usual (5 mg/kg/day) but this prescription had never been stopped by her physicians.
A. Laffitte, C. Masson, D. Chappard, E. Hoppé, M. Audran   +4 more
core   +4 more sources

Comparison of Piezoelectric and High‐Speed Drills for Frontal Beak Osteotomy in Endoscopic Sinus Surgery—Exploratory Study

Clinical Otolaryngology, EarlyView.
ABSTRACT Introduction Frontal beak reduction is a critical and challenging step in endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS). Traditional high‐speed drills can risk thermal injury and soft tissue trauma, whereas piezoelectric surgery uses ultrasonic vibrations for selective bone cutting and may improve surgical precision.
Łukasz Skrzypiec, Kornel Szczygielski, Agnieszka Brociek‐Piłczyńska, Dariusz Jurkiewicz, Marta Aleksandra Kwiatkowska   +4 more
wiley   +1 more source

Molecular effect of an OPTN common variant associated to Paget's disease of bone [PDF]

, 2018
Paget's disease of bone (PDB) is a chronic bone disorder and although genetic factors appear to play an important role in its pathogenesis, to date PDB causing mutations were identified only in the Sequestosome 1 (SQSTM1) gene at the PDB3 locus.
Brown, Jacques P., Cancela, M. Leonor, Conceição, Natércia, Gagnon, Edith, Michou, Laetitia, Silva, Iris   +5 more
core   +3 more sources

Investigating the Effect of Tumour Necrosis Factor Antagonist on Olfaction

Clinical Otolaryngology, EarlyView.
ABSTRACT Objectives Tumour Necrosis factor antagonists is a potent anti‐inflammatory medication and has shown to improve olfactory function in murine models. The primary aim was to determine the effect of TNF antagonists on olfactory performance in humans.
Andreas Espehana, George Macfarlane, Elizabeth Mairenn Garden, Liam Lee, Gabija Klyvyte, Lavandan Jegatheeswaran, Rebecca Davies, Carl Philpott   +7 more
wiley   +1 more source