Results 201 to 210 of about 104,655 (260)

YTHDF2 in hepatocellular carcinoma: Bridging m6A modification and cancer progression

VIEW, EarlyView.
Abstract YTH N6‐methyladenosine RNAbinding protein F2 (YTHDF2) is an N6‐methyladenosine (m6A) reader protein that mainly regulates the stability of methylated transcripts through mRNA decay. In the liver, YTHDF2 is involved in metabolic homeostasis, oxidative stress responses, and immune regulation.
Sijie Zang, Dongxue Ge, Wanqi Yang, Haobin Shen, Weihong Ge, Li Li, Dayu Chen, Jinglin Wang   +7 more
wiley   +1 more source

Interrogating the Glycolytic Axis in Pulmonary Hypertension Models: Potential Targets for Therapy. [PDF]

Pulm Circ
Sutcliffe RL, Cuthbertson I, Moore S, Southwood M, de La Bastida Casero L, Dunmore B, Marciniak SJ, Upton P, Morrell N, Caruso P, Soon E.   +10 more
europepmc   +1 more source

Advent of NK3R Antagonists for the Treatment of Menopausal Hot Flushes: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT The menopause transition is marked by symptoms predominantly attributed to declining oestrogen levels. Approximately 80% of women experience associated symptoms, and 25% experience severe symptoms. The commonest are vasomotor symptoms (VMS), collectively referring to hot flushes and/or night sweats.
Aaran H. Patel, Aureliane Pierret, Edouard G. Mills, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Dasatinib and Pulmonary Arterial Hypertension: When Cardio-Oncology Meets the Pulmonary Circulation. [PDF]

JACC Case Rep
Sreedhara K, Ghawanmeh M, Gomberg-Maitland M.   +2 more
europepmc   +1 more source

Temporal Trends in Pregnancy Outcomes Among Parents With Type 1 Diabetes: A Nationwide Register‐Based Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To assess temporal trends in outcomes of pregnancies with maternal or paternal type 1 diabetes compared to the general population. Design Register‐based study. Setting Denmark. Population 1 551 893 pregnancies from 1997 to 2021, hereof 5478 with maternal and 8072 with paternal type 1 diabetes.
Tina Wullum Gundersen, Sine Knorr, Lene Ringholm, Dorte Moeller Jensen, Peter Damm, Karoline Kragelund Nielsen, Helena Backman, Jeannet Lauenborg, Elisabeth Reinhardt Mathiesen, Anne Helby Petersen, Niels Skipper, Allan Kofoed‐Enevoldsen, Tine Dalsgaard Clausen   +12 more
wiley   +1 more source

Tirzepatide Attenuates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension: Association with the SIRT1/H4K12la/c-Jun Axis. [PDF]

Cells
Zhan S, Deng Y, Chen P, Lv T, Song Y, Liu J, Kong C.   +6 more
europepmc   +1 more source

Prediction of 10‐Year Incident Hypertension After Pregnancy: A Population‐Based Cohort Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To develop a model including pregnancy‐related factors for the prediction of incident hypertension after pregnancy and to assess the impact of pregnancy‐related factors on model performance. Design Population‐based cohort study. Setting Routine primary care data linked to the data from the Dutch Perinatal Registry and Statistics ...
Zhixun Yang, Hendrikus J. A. Van Os, Janet M. Kist, Rimke C. Vos, Tobias N. Bonten, Niels H. Chavannes, Hedwig M. M. Vos, Annelieke H. J. Petrus   +7 more
wiley   +1 more source

Alamandine/MrgD pathway modulates gut–bone marrow axis in ageing

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Ageing is associated with colon epithelial barrier disruption and up‐regulation of myelopoiesis in the bone marrow (BM). Alamandine (Ala) and MrgD are novel members of the renin angiotensin system (RAS). This study tested the hypothesis that Ala restores the colon epithelial barrier integrity in ageing via modulating gut–
Kishore Chittimalli, Henryata E. Rozario, Victor Martinez, Zachary L. McAdams, Stephen A. Adkins, Aaron C. Ericsson, Yagna P. R. Jarajapu   +6 more
wiley   +1 more source

R2Tg retrotransposon mediated targeted integration of exogenous genes into the 28S rDNA locus in mammalian cell lines for PKU gene therapy. [PDF]

Front Genome Ed
Wang X, Wen Z, Xu R, Shi W, Long Y, Zhan X, Su R, Fei J, Li Y.   +8 more
europepmc   +1 more source