Results 81 to 90 of about 104,655 (260)

Overview of methods for determining polycyclic aromatic hydrocarbons in cigarette smoke, ETHS and ENDS aerosole, liquids for ENDS

Новые технологии, 2019
The problem of improving the quality and reducing the toxicity of tobacco products is relevant and directly related to health. In 2008 the Russian Federation joined the WHO FCTC (Framework Convention of the World Health Organization on Tobacco Control ...
T. A. Zaitseva
doaj   +1 more source

Initial treatment strategies and outcomes across haemodynamic thresholds and risk stratification in incident systemic sclerosis–associated pulmonary arterial hypertension: a EUSTAR analysis

Arthritis &Rheumatology, Accepted Article.
Objective Real‐world initial treatment strategies in SSc‐PAH remain incompletely described. We aimed to characterise these strategies across haemodynamic thresholds and risk strata and evaluate outcome associations. Methods We analysed treatment‐naïve SSc‐PAH patients in EUSTAR (2000–2021) fulfilling the 2022 haemodynamic definition.
Hilde Jenssen Bjørkekjær, Cosimo Bruni, Kaspar Broch, Cathrine Brunborg, Patricia E Carreira, Paolo Airò, Carmen Pilar Simeón‐Aznar, Marie‐Elise Truchetet, Alessandro Giollo, Alexandra Balbir‐Gurman, Mickael Martin, Christopher P Denton, Armando Gabrielli, Francesco Del Galdo, Madelon C. Vonk, Håvard Fretheim, Helle Bitter, Øyvind Midtvedt, Arne K. Andreassen, Sverre Høie, Yoshiya Tanaka, Gabriela Riemekasten, Ulf Müller‐Ladner, Marco Matucci‐Cerinic, Ivan Castellví, Elise Siegert, Eric Hachulla, Øyvind Molberg, Oliver Distler, Anna‐Maria Hoffmann‐Vold, on behalf of the EUSTAR collaborators   +30 more
wiley   +1 more source

Sema4A neutralization reduces fibrosis and inflammation in a mouse model of systemic sclerosis and a 3D model of immunity‐driven fibrosis

Arthritis &Rheumatology, Accepted Article.
Objective We previously showed that Semaphorin4A (Sema4A) is elevated in patients with systemic sclerosis (SSc) and promotes inflammation and fibrosis in vitro. Here, we examined the effect of Sema4A neutralization in vivo and in 3D fibrosis models. Methods Sema4A plasma levels were measured by ELISA in healthy controls (n=31) and patients with SSc (n=
Jaime Marty, Sara Martinez‐Ramos, Carlos Rafael‐Vidal, Beatriz Malvar‐Fernández, Tiago Carvalheiro, Ralph G. Tieland, Ines Ramos, Wiola Marut, Ana Pinheiro‐Lopes, Ana Argibay, Brenda Maure, Caritina Vázquez‐Triñanes, Nair Pérez Gómez, David Fernández‐Fernández, Sandra Vila, Coral Mouriño, Rogier M Thurlings, Arjan van Caam, Alberto Rivera, José María Pego‐Reigosa, Timothy R. Radstake, Samuel Garcia   +21 more
wiley   +1 more source

Polycyclic aromatic hydrocarbons as limiting parameters in traditional production of dry-cured meat products [PDF]

Food and Feed Research
The goal of the study was to investigate the concentration of 16 US EPA polycyclic aromatic hydrocarbons (PAHs) and check the sensory properties in 11 dry-cured meat products, smoked in three different ways (atmospheric simulation chamber (ATMOS ...
Vranešević Jelena M., Vidaković-Knežević Suzana L., Kartalović Brankica D., Škaljac Snežana B., Plavša Nada P., Mastanjević Krešimir M., Novakov Nikolina J.   +6 more
doaj   +1 more source

Adaptive imatinib regimens can mitigate cumulative toxicity while sustaining hemodynamic benefit: A model‐based simulation of the positioning imatinib for pulmonary arterial hypertension trial

British Journal of Clinical Pharmacology, EarlyView.
ABSTRACT Aims Imatinib improves hemodynamics in pulmonary arterial hypertension (PAH), but dose‐dependent toxicity has limited its clinical development. We aimed to quantify the dose–efficacy–toxicity relationship and evaluate alternative dosing strategies using data from the PIPAH trial.
Medhat M. Said, Robert B. de Mooij, Dian Jiao, Reitze J. Ovelgonne, Rami Biram, Juan Delgado‐SanMartin, Alexander M. K. Rothman, Sofia S. Villar, Andreas A. Roussakis, Jurjan Aman, Ron A. A. Mathôt, Eleonora L. Swart, Martin R. Wilkins, Imke H. Bartelink   +13 more
wiley   +1 more source

CYP3A5 genetic variability influences sildenafil and metabolite in pulmonary hypertension

British Journal of Clinical Pharmacology, EarlyView.
Aim Interindividual variability in sildenafil response among pulmonary hypertension patients (PH) may be influenced by CYP3A5 polymorphisms. CYP3A5*3 allele reduces CYP3A5 activity and affects sildenafil metabolism. This study investigated the associations between CYP3A5 genotype and plasma concentrations of sildenafil and N‐desmethyl sildenafil, as ...
Pranisa Wongwien, Burabha Pussadhamma, Sirimas Kanjanawart, Thikhumporn Areesinpitak, Nontaya Nakkam, Chingching Foocharoen, Wichittra Tassaneeyakul, Suda Vannaprasaht   +7 more
wiley   +1 more source

Contamination of runoff waters with polycyclic aromatic hydrocarbons in the city of Siedlce

Environmental Protection and Natural Resources, 2016
The paper presents the results of the research on content of 16 polycyclic aromatic hydrocarbons in samples of runoff waters collected in Siedlce city. The samples were collected in March, July and October 2015. The highest mean total concentration of 16
Kluska Mariusz, Łopuszyńska Beata, Jabłońska Joanna   +2 more
doaj   +1 more source

PAH in contaminated sediment: review of suitability of PAH- components/groups for assessment of remediation needs

, 2016
-I Norge er det utarbeidet klassegrenser for til sammen 16 PAH-forbindelser i sediment og vann. Grenseverdiene baserer seg på kunnskap om toksisitet av de ulike stoffene og hva som er akseptabel eksponering for miljøet.
Breedveld, Gijs D., Grung, Merete, Ruus, Anders, Arp, Hans Petter Heinrich, Oen, Amy M P   +4 more
core  

Effectiveness of PAH Specific Treatment Is Comparable Between PAH Associated With Connective Tissue Disease and Idiopathic PAH: Data From the Multicentre National Registry

Pulmonary arterial hypertension (PAH) is a rare disease with poor prognosis. The same treatment is recommended in patients with PAH associated with connective tissue disease (CTD) and idiopathic PAH (IPAH).
Ewa Malinowska, Katarzyna Betkier‐Lipińska, Marta Banaszkiewicz, Ilona Skoczylas, Łukasz Chrzanowski, Zbigniew Gąsior, Ewa Lewicka, Grzegorz Kopeć, Miłosz Jaguszewski, Wojciech Jacheć, Tatiana Mularek‐Kubzdela, Michał Ciurzyński, Grzegorz Grześk, Katarzyna Mizia‐Stec, Marcin Waligóra, Piotr Błaszczak, Anna Smukowska‐Gorynia, Katarzyna Ptaszyńska, Marcin Kurzyna, Katarzyna Widejko, Michał Tomaszewski, Piotr Pruszczyk, Judyta Winowska‐Józwa, Sylwia Iwańczyk, Małgorzata Peregud‐Pogorzelska, Ewa Mroczek, Agnieszka Pawlak   +26 more
core   +1 more source

Influence of sugar cane burning in the levels PAH, nitro-PAH and oxy-PAH associated to atmospheric particulate matter

, 2014
Os hidrocarbonetos policíclicos aromáticos (HPAs) e seus derivados nitrados (nitro-HPAs) e oxigenados (oxi-HPAs) são compostos de grande interesse devido seus efeitos deletérios à saúde.
Souza, Kely Ferreira de, Kely Ferreira de Souza   +1 more
core   +1 more source