Results 191 to 200 of about 88,259 (271)

Stereotactic body radiotherapy plus cadonilimab (PD‐1/CTLA‐4 bispecific antibody) as third‐line or beyond therapy for refractory solid tumors: A phase 1b study

open access: yesCancer Communications, Volume 45, Issue 10, Page 1235-1246, October 2025.
Abstract Background Cadonilimab is a humanized immunoglobulin G1 bispecific antibody targeting programmed cell death protein 1 (PD‐1) and cytotoxic T‐lymphocyte‐associated antigen 4 (CTLA‐4). This study aimed to evaluate the safety and efficacy of stereotactic body radiotherapy (SBRT) combined with cadonilimab in patients with advanced recurrent or ...
Yao Xiao   +7 more
wiley   +1 more source

Early Recognition of Infantile Systemic Hyalinosis in a Palestinian Infant: A Case Report

open access: yesClinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Infantile systemic hyalinosis should be suspected in infants with contractures, skin changes, and diarrhea in consanguineous families. Early recognition allows timely genetic testing, supportive care, and counseling, improving family outcomes despite poor prognosis.
Lilyan Jarrar   +6 more
wiley   +1 more source

Neuromyelitis Optica Mimicking Multiple Sclerosis: A Case Report and a Comprehensive Review of the Literature

open access: yesClinical Case Reports, Volume 13, Issue 10, October 2025.
Post‐gadolinium enhancement of the spinal cord seen in NMO. ABSTRACT Neuromyelitis optica spectrum disorder (NMOSD) may mimic other neurological conditions, including multiple sclerosis (MS). We report a 25‐year‐old woman with hypothyroidism and depression who presented with progressive quadriparesis.
Sunil Thatal   +6 more
wiley   +1 more source

Indications for surgery versus conservative treatment in the management of lumbar disc herniations: A systematic review. [PDF]

open access: yesBrain Spine
Thavarajasingam SG   +13 more
europepmc   +1 more source

Consolidation, Systematic Appraisal and Comparison of Guideline Recommendations Regarding Management of Chronic Pain: Protocol for a Digital Chronic Pain Recommendation Map

open access: yesClinical and Public Health Guidelines, Volume 2, Issue 4, October 2025.
ABSTRACT Introduction Chronic pain affects 1 in 5 adults and children globally; however, management remains highly variable and low value care is common. Inconsistent recommendations among clinical practice guidelines for management of chronic pain contribute to suboptimal patient management.
Andrea J. Darzi   +48 more
wiley   +1 more source

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