Automated MRI Segmentation of Brainstem Nuclei Critical to Consciousness
To advance coma and consciousness research, we developed a method for segmenting brainstem ascending arousal network nuclei from MRI scans. We validated automated segmentations of these nuclei in normative brain scans from multiple MRI modalities, as well as in patients with Alzheimer's disease and traumatic brain injury.
Mark D. Olchanyi+12 more
wiley +1 more source
The role of the cingulum in deep brain stimulation of the limbic pain matrix. [PDF]
Kinfe T.
europepmc +1 more source
The Management of Head and Neck Lymphoedema: A 2025 Systematic Review
ABSTRACT Background Head and Neck Lymphoedema (HNL) is debilitating to many domains of patients' structure and function, yet it is the most poorly researched form of lymphoedema. This is due to the variety of signs and symptoms experienced by HNL patients, and this makes it difficult to formulate standardized staging classifications and treatment ...
Rohan Rajaram+4 more
wiley +1 more source
A Case of Miller−Fisher Overlap Syndrome With Positive Anti‐GM4 Antibody and Atypical Symptoms
ABSTRACT Background Miller−Fisher syndrome (MFS) is a recognized clinical variant of Guillain−Barré syndrome (GBS), characterized by the classic triad of ophthalmoplegia, ataxia, and areflexia. When accompanied by additional symptoms such as bulbar palsy, limb weakness, or lethargy, it is termed MFS overlap syndrome.
Miao Tang+9 more
wiley +1 more source
Intrathecal baclofen therapy can improve spasticity associated with infantile-onset dentatorubral-pallidoluysian atrophy: illustrative cases. [PDF]
Nakagawa T+11 more
europepmc +1 more source
This retrospective case series evaluated the use of perforator‐plus peninsular flaps (PPPF) and modified keystone flaps (MKF) in 10 patients with head and neck defects classified as “uneasy” under a descriptive framework. All flaps survived without complications, and scar outcomes were assessed using the Patient and Observer Scar Assessment Scale ...
Chi Sun Yoon+4 more
wiley +1 more source
Prolonged Pre-Eruptive Phase of Herpes Zoster Ophthalmicus in Immunocompetent Athlete: A Case of Delayed Diagnosis and Management Challenges. [PDF]
Kumar S+4 more
europepmc +1 more source
Proteolysis‐Targeting Chimera (PROTAC): Current Applications and Future Directions
PROTACs are reshaping drug discovery through targeted protein degradation. Clinical programs now extend to prostate, breast, lung, hematologic, and solid tumors, with key targets including AR, ER, BTK, STAT3, Bcl‐xL, BRD9, Kras, and so on. These degraders overcome resistance, broaden therapeutic scope, and provide solutions for “undruggable” proteins ...
Gang Fan+9 more
wiley +1 more source
Esophageal Hematoma Following Transcatheter Edge-to-Edge Repair of the Mitral Valve: A Rare Complication of Transesophageal Echocardiography. [PDF]
Aref A+6 more
europepmc +1 more source