Results 61 to 70 of about 163,532 (256)

Cough, chest pain and haemoptysis in a young nurse [PDF]

open access: yesEuropean Respiratory Journal, 1996
Case report A 26 year old female nurse, of East African origin, presented with a 4 month history of intermittent cough, left-sided chest pain in the upper region, and mild haemoptysis for 2 days prior to admission. She gave a history of low grade intermittent fever and night sweats, and weight loss of about 3 kg over the previous 4 months, but denied ...
openaire   +2 more sources

Evaluating a virtual paediatric adverse drug reaction clinic

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Adverse drug reactions (ADRs) are a common problem in paediatric health care. There is limited access to expertise in the evaluation and management of potential ADRs in children, limiting access to these services and creating delays in assessment and management.
Emily Hauck   +2 more
wiley   +1 more source

Pharmacokinetics and safety of tezepelumab in children with mild, moderate or severe asthma and adolescents with mild‐to‐moderate asthma

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Tezepelumab is a human monoclonal antibody that blocks the activity of thymic stromal lymphopoietin and is approved for adolescents and adults with severe asthma. This analysis assessed pharmacokinetics (PK), pharmacodynamics and safety of tezepelumab up to 85 days postdose in adolescents and children.
Anna Lundahl   +14 more
wiley   +1 more source

Safety and pharmacokinetics of inhaled aloxistatin: A first‐in‐human phase 1 dose escalation trial

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Aloxistatin (E64d) is a membrane‐permeable cysteine protease inhibitor prodrug that is converted by esterases to the active metabolite E64c (loxistatin). This first‐in‐human study evaluated the safety, tolerability and pharmacokinetics of single ascending doses of inhaled E64d in healthy volunteers.
Sebastian Fähndrich   +24 more
wiley   +1 more source

Toward Fit‐for‐Purpose Data for Drug Assessment in Non‐small Cell Lung Cancer: A Core Dataset

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Considering the high unmet medical need in people with non‐small cell lung cancer (NSCLC), the drug assessment for targeted therapies often rely on small populations and single‐arm trials, challenging the evaluation by regulatory authorities, health technology assessment bodies (HTAb), and clinicians.
Geeske F. Grit   +6 more
wiley   +1 more source

Cough syncope induced by post nasal drip successfully managed by Gabapentin

open access: yesRespiratory Medicine Case Reports, 2017
Syncope is a common complaint in both neurology clinic and emergency department. It is defined as transient loss of consciousness with loss of postural tone, which is usually self-limited and followed by a spontaneous recovery.
Hussein Algahtani, Bader Shirah
doaj   +1 more source

Effects of ultrasound-guided erector spinae plane block on postoperative acute pain and chronic post-surgical pain in patients underwent video-assisted thoracoscopic lobectomy: a prospective randomized, controlled trial

open access: yesBMC Anesthesiology, 2023
Objective To investigate the effects of ultrasound-guided erector spinae plane block (ESPB) on acute and chronic post-surgical pain in patients underwent video-assisted thoracoscopic lobectomy.
Jie Zhang   +5 more
doaj   +1 more source

COMPARISON OF THE EFFECT OF INTRA-CUFF KETAMINE VERSUS ALKALINIZED LIDOCAINE FOR PREVENTION OF POST-OPERATIVE SORE THROAT

open access: yesPakistan Armed Forces Medical Journal, 2021
Objective: To determine the Comparison of the effect of intra-cuff ketamine versus alkalinized lidocaine for prevention of post-operative sore throat at a tertiary care hospital at Karachi. Study Design: Prospective comparative study.
Nadeem Naqvi   +3 more
doaj   +4 more sources

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development

open access: yesEpilepsia, EarlyView.
Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer   +7 more
wiley   +1 more source

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