Results 91 to 100 of about 5,652,392 (296)

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Caregiver Pain Medicine Questionnaire (CPMQ).

, 2004
The CPMQ is a 22-item self-report instrument. Each item is scored on a five-point Likert scale of agreement ((1 = strongly disagree; 5 = strongly agree). Higher number indicates a high level of agreement and greater concern about managing pain issues.The
Marijo Letizia, Steve Creech, Ellen Norton, Marie Shanahan,Lori Hedges.
core  

The prevalence of pain at pressure areas and pressure ulcers in hospitalised patients. [PDF]

, 2013
Background: Patients with pressure ulcers (PUs) report that pain is their most distressing symptom, but there are few PU pain prevalence studies. We sought to estimate the prevalence of unattributed pressure area related pain (UPAR pain) which was ...
Rivers, Carly, McGinnis, Elizabeth, Coleman, S, Wilson, L, McGinnis, E, Briggs, Michelle, Michelle Collinson, Rivers, C, Nelson, EA, Briggs, M; id_orcid, Susanne Coleman, Collinson, Michelle, Stevenson, Rebecca, Dealey, C, Stubbs, N, Dealey, Carol, Carly Rivers, E Andrea Nelson, Jane Nixon, Michelle Briggs, Briggs, M, Nixon, J, Stevenson, R, Lyn Wilson, Nikki Stubbs, Brown, Julia, Nelson, E Andrea; id_orcid, Collinson, M, Coleman, Susanne, Elizabeth McGinnis, Nixon, Jane, Rebecca Stevenson, Wilson, Lyn, Julia Brown, Stubbs, Nikki, Carol Dealey, Brown, J   +36 more
core   +2 more sources

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

PAIN MEDICINE: A Pain Journal for the New Millennium [PDF]

Pain Medicine, 2000
The birth of PAIN MEDICINE heralds a new era for the study and clinical care of pain and for pain medicine as an internationally recognized specialty of medicine with its clinical and research partners in other disciplines. It is not entirely coincidental that the journal's birthday occurs simultaneously with the new millennium.
openaire   +2 more sources

Occupational health guidelines for the management of low back pain: an international comparison [PDF]

, 2003
The enormous socioeconomic burden of low back pain emphasises the need for effective management of this problem, especially in an occupational context.
Koes, Bart; id_orcid, Hlobil, H., van Tulder, MW; id_orcid, van Tulder, MW, Waddell, G., Staal, JB, Burton, A.K., van Mechelen, W, Koes, B. W., van Tulder, M.W., Koes, B.W., Staal, J. B., Staal, J.B., van Mechelen, W., Burton, AK, Burton, A. Kim, Burton, A. K., Hlobil, H, Waddell, G, Waddell, Gordon, van Tulder, M. W.   +20 more
core   +1 more source

A Low Psoas Muscle Index Was Associated With a Poorer Overall Survival in Patients Who Underwent Percutaneous Nephrostomy

Aging and Cancer, EarlyView.
In patients with malignant ureteral obstruction undergoing percutaneous nephrostomy, sarcopenia defined by a low psoas muscle index was independently associated with poor overall survival on multivariate Cox regression analysis, suggesting that preoperative assessment of psoas muscle index may aid prognostic stratification in this population.
Kota Shimokihara, Takashi Kawahara, Kazuhide Makiyama, Hiroji Uemura   +3 more
wiley   +1 more source

The “Continuum of Pain” and the American Academy of Pain Medicine [PDF]

Pain Medicine, 2015
We mark our Academy's end of year and beginning of the next with our March Annual Meeting. As I am writing my last President's Message (PM) in the first few days of January, I wanted to share with you some our accomplishments over the last year, as well as some of our goals and objectives in moving forward.
openaire   +2 more sources

UK back pain exercise and manipulation (UK BEAM) trial - national randomised trial of physical treatments for back pain in primary care: objectives, design and interventions [PDF]

, 2003
Low back pain has major health and social implications. Although there have been many randomised controlled trials of manipulation and exercise for the management of low back pain, the role of these two treatments in its routine management remains ...
null null, UK Beam (Back pain Exercise and Manipulation) Trial Team, Burton, A. Kim   +2 more
core   +2 more sources